ArticleJournal of neuroimmunology2009
Viral nanoparticles associate with regions of inflammation and blood brain barrier disruption during CNS infection.
Article in Journal of neuroimmunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Plant-derived nanocarriers & nanostructures for barrier-defined translation: a comprehensive review of mechanisms, targets, and translation.Journal of nanobiotechnology · 2026Review
- Genetically-engineered Salmonella typhimurium expressing FGF21 promotes neurological recovery in ischemic stroke via FGFR1/AMPK/mTOR pathway.Journal of neuroinflammation · 2025Article
- Delivery of mitoxantrone using a plant virus-based nanoparticle for the treatment of glioblastomas.Journal of materials chemistry. B · 2018Article
- Design of virus-based nanomaterials for medicine, biotechnology, and energy.Chemical Society reviews · 2016Review
- Intracellular delivery of antibodies by chimeric Sesbania mosaic virus (SeMV) virus like particles.Scientific reports · 2016Article
- Development of interspecific Solanum lycopersicum and screening for Tospovirus resistance.Saudi journal of biological sciences · 2015Article
- Virus-Based Nanoparticles as Versatile Nanomachines.Annual review of virology · 2015Review
- Bionanotechnology and the future of glioma.Surgical neurology international · 2015Article
- Using viruses as nanomedicines.British journal of pharmacology · 2014Review
- Cardioprotective activity of placental growth factor in a rat model of acute myocardial infarction: nanoparticle-based delivery versus direct myocardial injection.BMC cardiovascular disorders · 2014Article
- Infusion of imaging and therapeutic molecules into the plant virus-based carrier cowpea mosaic virus: cargo-loading and delivery.Journal of controlled release : official journal of the Controlled Release Society · 2013Article
- Cross-kingdom sequence similarities between human micro-RNAs and plant viruses.Communicative & integrative biology · 2013Article
- Endocytic uptake pathways utilized by CPMV nanoparticles.Molecular pharmaceutics · 2013Article
- Article
- Design of nanovectors for therapy and imaging of cardiovascular diseases.Methodist DeBakey cardiovascular journal · 2012Article
- Transferrin-mediated targeting of bacteriophage HK97 nanoparticles into tumor cells.Nanomedicine (London, England) · 2011Article
- Intramyocardial sustained delivery of placental growth factor using nanoparticles as a vehicle for delivery in the rat infarct model.International journal of nanomedicine · 2011Article
- Viral nanoparticles as platforms for next-generation therapeutics and imaging devices.Nanomedicine : nanotechnology, biology, and medicine · 2010Review
- Recent advances in nanotechnology based drug delivery to the brain.Cytotechnology · 2010Article
- Adaptive immune regulation of glial homeostasis as an immunization strategy for neurodegenerative diseases.Journal of neurochemistry · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Targeted treatment of inflammatory diseases of the central nervous system (CNS) remains problematic due to the complex pathogenesis of these disorders and difficulty in drug delivery. The plant virus, cowpea mosaic virus (CPMV), has recently been explored as a nanoparticle delivery system for therapeutics targeting a number of diseases including cancer and neurodegeneration. To understand the biodistribution of CPMV in the CNS, we examined CPMV uptake during infection of mice with neurotropic mouse hepatitis virus (MHV). CPMV localized mainly to the CNS endothelium in areas that contained an intact blood brain barrier. However, in inflammatory lesions containing macrophage/microglial cell infiltration and IgG, CPMV could be detected in the brain parenchyma. Furthermore, CPMV showed rapid internalization in an in vitro model of the BBB. These results suggest that CPMV particles could be used as a vehicle to deliver therapeutics to the damaged CNS during neurodegenerative and infectious diseases of the CNS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.