Trial reportJournal of vascular surgery2009
Systemic inflammation, coagulopathy, and acute renal insufficiency following endovascular thoracoabdominal aortic aneurysm repair.
Trial report in Journal of vascular surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03208920 (Omega EVAR), which is not on this map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Omega EVAR: Use of Fish Oil to Reduce Inflammation During Endovascular Abdominal Aortic Repair.
Who cites it
23 citing papers in PubMed, 71 citations in OpenAlex.
- NETosis Markers (ssDNA, dsDNA) as Predictors of Mortality and Hospitalization After Endovascular Aortic Repair.International journal of molecular sciences · 2026Article
- Inflammation-Based Cell Ratios Beyond White Blood Cell Count for Predicting Postimplantation Syndrome After EVAR and TEVAR.International journal of molecular sciences · 2025Article
- Evaluation of Coagulation Factors and Platelet Activation in Patients Undergoing Complex Endovascular Para-Renal and Thoraco-Abdominal Aneurysm Repair: The Protocol of a Prospective Observational Study.Journal of clinical medicine · 2025Article
- Comparison of EndoSuture vs fenestrated aortic aneurysm repair in treatment of abdominal aortic aneurysms with unfavorable neck anatomy.Journal of vascular surgery · 2025Article
- Determination of Risk Factors for Postoperative Acute Kidney Injury in Patients With Gynecologic Malignancies.Cureus · 2023Article
- Evaluation of selected parameters of inflammation, coagulation system, and formation of extracellular neutrophil traps (NETs) in the perioperative period in patients undergoing endovascular treatment of thoracoabdominal aneurysm with a branched device (t-Branch).Frontiers in cardiovascular medicine · 2023Article
- Platelet function changes in patients undergoing endovascular aortic aneurysm repair: Review of the literature.Frontiers in cardiovascular medicine · 2022Review
- Perioperative management of patients undergoing thoracic endovascular repair.Annals of cardiothoracic surgery · 2021Review
- Unusual hybrid repair of a thoracoabdominal and mesenteric aneurysm with aberrant right hepatic artery.Journal of vascular surgery cases and innovative techniques · 2021Article
- Lipocalin-2 Variants and Their Relationship With Cardio-Renal Risk Factors.Frontiers in endocrinology · 2021Article
- Endovascular Treatment for Thoracoabdominal Aortic Aneurysm and Complex Abdominal Aortic Aneurysm Using Fenestrated and Branched Grafts.Interventional radiology (Higashimatsuyama-shi (Japan) · 2020Review
- Red blood cell distribution width (RDW) is an independent predictor of post-implantation syndrome in patients undergoing endovascular aortic repair for abdominal aortic aneurysm.Annals of translational medicine · 2018Article
- Urine neutrophil gelatinase-associated lipocalin predicts outcome and renal failure in open and endovascular thoracic abdominal aortic aneurysm surgery.Scientific reports · 2018Article
- Volume of mural thrombus plays a role in the elevation of inflammatory markers after endovascular aortic repair.Journal of cardiothoracic surgery · 2018Observational
- Complications of endovascular aneurysm repair of the thoracic and abdominal aorta: evaluation and management.Cardiovascular diagnosis and therapy · 2018Review
- Risk factors and early outcomes of acute renal injury after thoracic aortic endograft repair for type B aortic dissection.Therapeutics and clinical risk management · 2017Article
- Neutrophil Gelatinase Associated Lipocalin (NGAL) as a Biomarker. Does It Apply in Abdominal Aortic Aneurysms? A Review of Literature.The Indian journal of surgery · 2015Review
- An Update on the Inflammatory Response after Endovascular Repair for Abdominal Aortic Aneurysm.Mediators of inflammation · 2015Review
- Impact of graft composition on the systemic inflammatory response after an elective repair of an abdominal aortic aneurysm.Annals of surgical treatment and research · 2015Article
- Early prediction of acute kidney injury biomarkers after endovascular stent graft repair of aortic aneurysm: a prospective observational study.Journal of intensive care · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo characterize the inflammatory and coagulopathic response after endovascular thoracoabdominal aortic aneurysm (TAAA) repair and to evaluate the effect of the response on postoperative renal function.
methodsFrom July 2005 to June 2008, 42 patients underwent elective endovascular repair of a TAAA using custom designed multi-branched stent-grafts at a single academic institution. Four patients were excluded from the analysis. White blood cell count (WBC), platelet count, prothrombin time (PT), and creatinine were measured in all patients. In the last nine patients, interleukin-6 (IL-6), protein C, Factor V, d-dimers, cystatin C, and neutrophil gelatinase-associated lipocalin (NGAL) levels were also measured. Change in lab values were expressed as a percentage of baseline values.
resultsThe 30-day mortality rate was 5% (2/38). All patients (n = 38) had a higher WBC (mean +/- SD: 139 +/- 80%, P < .0001), lower platelet count (56 +/- 15%, P < .0001), and higher PT (median: 17%, Interquartile range (IQR) 12%-22%, P < .0001) after stent-graft insertion. Twelve of 38 patients (32%) developed postoperative acute renal insufficiency (>50% rise in creatinine). Patients with renal insufficiency had significantly larger changes in WBC (178 +/- 100% vs 121 +/- 64%, P = .04) and platelet count (64 +/- 17% vs 52 +/- 12%, P = .02) compared with those without renal insufficiency. All patients (n = 9) had significant increases in NGAL (182 +/- 115%, P = .008) after stent-graft insertion. Six of nine patients (67%) had increased cystatin C (35 +/- 43%, P = .04) after stent-graft insertion, with a greater rise in those with postoperative renal insufficiency (87 +/- 32% vs 8 +/- 13%, P = .02). IL-6 levels were markedly increased in all patients (n = 9) after repair (9840 +/- 6160%, P = .008). Protein C (35 +/- 10%, P = .008) and Factor V levels (28 +/- 20%, P = .008) were uniformly decreased, while d-dimers were elevated after repair in all patients (310 +/- 213%, P = .008).
conclusionsLeukocytosis and thrombocytopenia were uniform following endovascular TAAA repair, and the severity of the response correlated with post-operative renal dysfunction. Elevation of a sensitive marker of renal injury (NGAL) suggests that renal injury may occur in all patients after stent-graft insertion.
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