ReviewThe international journal of biochemistry & cell biology2009
Multi-scale mechanics from molecules to morphogenesis.
Review in The international journal of biochemistry & cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Shape, Strain, and Stability: Epithelia Under High Strain.bioRxiv : the preprint server for biology · 2025Article
- The TissueTractor: A Device for Applying Large Strains to Tissues and Cells for Simultaneous High-Resolution Live Cell Microscopy.Small methods · 2025Article
- Measuring and manipulating mechanical forces during development.Nature cell biology · 2025Review
- Unsupervised spatiotemporal classification of deformation patterns of embryonic tissues matches their fate map.iScience · 2025Article
- The Mechanics of Building Functional Organs.Cold Spring Harbor perspectives in biology · 2025Review
- The TissueTractor, a device for applying large strains to tissues and cells for simultaneous high-resolution live cell microscopy.bioRxiv : the preprint server for biology · 2024Article
- Non-contact and label-free biomechanical imaging: Stimulated Brillouin microscopy and beyond.Frontiers in physics · 2023Article
- Image-based parameter inference for epithelial mechanics.PLoS computational biology · 2022Article
- First trimester mechanisms of gestational sac placental and foetal teratogenicity: a framework for birth cohort studies.Human reproduction update · 2021Review
- Nuclear Deformation Causes DNA Damage by Increasing Replication Stress.Current biology : CB · 2021Article
- Tracking intracellular forces and mechanical property changes in mouse one-cell embryo development.Nature materials · 2020Article
- Decoupling the Roles of Cell Shape and Mechanical Stress in Orienting and Cueing Epithelial Mitosis.Cell reports · 2019Article
- Tools to reverse-engineer multicellular systems: case studies using the fruit fly.Journal of biological engineering · 2019Review
- Living tissues are more than cell clusters: The extracellular matrix as a driving force in morphogenesis.Progress in biophysics and molecular biology · 2018Review
- Mechanocellular models of epithelial morphogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- A toolbox to explore the mechanics of living embryonic tissues.Seminars in cell & developmental biology · 2016Review
- Force transmission in epithelial tissues.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Review
- Emergent material properties of developing epithelial tissues.BMC biology · 2015Article
- Force production and mechanical accommodation during convergent extension.Development (Cambridge, England) · 2015Article
- Mechanics of blastopore closure during amphibian gastrulation.Developmental biology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Dynamic mechanical processes shape the embryo and organs during development. Little is understood about the basic physics of these processes, what forces are generated, or how tissues resist or guide those forces during morphogenesis. This review offers an outline of some of the basic principles of biomechanics, provides working examples of biomechanical analyses of developing embryos, and reviews the role of structural proteins in establishing and maintaining the mechanical properties of embryonic tissues. Drawing on examples we highlight the importance of investigating mechanics at multiple scales from milliseconds to hours and from individual molecules to whole embryos. Lastly, we pose a series of questions that will need to be addressed if we are to understand the larger integration of molecular and physical mechanical processes during morphogenesis and organogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.