ArticleGene2009
The serpin gene family in Anopheles gambiae.
Article in Gene, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- Serpin-4 Negatively Regulates Prophenoloxidase Activation and Antimicrobial Peptide Synthesis in the Silkworm,International journal of molecular sciences · 2023Article
- A Genome-Wide Analysis of Serine Protease Inhibitors inInternational journal of molecular sciences · 2023Article
- The Chromosome-Level Genome Assembly of Bean Blossom Thrips (International journal of molecular sciences · 2023Article
- Identification and functional analysis of serine protease inhibitor gene family ofFrontiers in physiology · 2023Article
- Aryl hydrocarbon receptor and Krüppel like factor 10 mediate a transcriptional axis modulating immune homeostasis in mosquitoes.Scientific reports · 2022Article
- A serpin (CvT-serpin15) of teratocytes contributes to microbial-resistance in Plutella xylostella during Cotesia vestalis parasitism.Pest management science · 2021Article
- Inhibition of immune pathway-initiating hemolymph protease-14 by Manduca sexta serpin-12, a conserved mechanism for the regulation of melanization and Toll activation in insects.Insect biochemistry and molecular biology · 2020Article
- The Manduca sexta serpinome: Analysis of serpin genes and proteins in the tobacco hornworm.Insect biochemistry and molecular biology · 2018Article
- Hemolymph proteins of Anopheles gambiae larvae infected by Escherichia coli.Developmental and comparative immunology · 2017Article
- Anopheles gambiae larvae mount stronger immune responses against bacterial infection than adults: evidence of adaptive decoupling in mosquitoes.Parasites & vectors · 2017Article
- Characterization and expression profiling of serine protease inhibitors in the diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae).BMC genomics · 2017Article
- A Venom Serpin Splicing Isoform of the Endoparasitoid Wasp Pteromalus puparum Suppresses Host Prophenoloxidase Cascade by Forming Complexes with Host Hemolymph Proteinases.The Journal of biological chemistry · 2017Article
- Article
- 1.45 Å resolution structure of SRPN18 from the malaria vector Anopheles gambiae.Acta crystallographica. Section F, Structural biology communications · 2016Article
- RNAi Trigger Delivery into Anopheles gambiae Pupae.Journal of visualized experiments : JoVE · 2016Article
- Genetic Structure of a Local Population of the Anopheles gambiae Complex in Burkina Faso.PloS one · 2016Article
- Bioinformatic analyses of male and female Amblyomma americanum tick expressed serine protease inhibitors (serpins).Ticks and tick-borne diseases · 2015Article
- The role played by alternative splicing in antigenic variability in human endo-parasites.Parasites & vectors · 2014Review
- RNAi-mediated knockdown of serine protease inhibitor genes increases the mortality of Plutella xylostella challenged by destruxin A.PloS one · 2014Article
- Manduca sexta serpin-7, a putative regulator of hemolymph prophenoloxidase activation.Insect biochemistry and molecular biology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Serpins (serine protease inhibitors) regulate some innate immune responses of insects by inhibiting endogenous proteases. In this study, we characterized the serpin (SRPN) gene family in the mosquito Anopheles gambiae, the major malaria vector in Sub-Saharan Africa. We identified 18 A. gambiae SRPN genes, all on chromosomes 2 and 3, through searches of genomic DNA and EST databases. In addition to SRPN10, previously documented to exhibit alternative splicing, we found three splicing isoforms of SRPN4. We completed sequencing of cDNAs for the A. gambiae serpins to obtain complete coding sequence information and to verify or improve gene predictions. The predicted SRPN9 and 15 in the initial genome annotation were determined to be a single gene (SRPN9). Sixteen of the serpins contained putative secretion signal sequences. Multiple sequence alignments showing conserved residues important in structural conformation, including the consensus pattern within the hinge region, indicated that most of the A. gambiae serpins may be inhibitory. Phylogenetic analyses confirmed that SRPN1, 2, 3, 8, 9 and 10 formed phylogenetic clusters with known inhibitory serpins from Drosophila melanogaster and Manduca sexta. Many of the A. gambiae serpins were expressed during all life stages. However, SRPN7, 8, 12, and 19 were expressed at very low levels in the adult stage. SRPN13 was expressed mostly in eggs and young larvae, whereas SRPN5 and 14 were expressed mostly in adults. Such differences in expression pattern suggest that the serpins are involved in multiple physiological processes. Determining the biological functions of the mosquito serpins will require future work to identify the proteases they inhibit in vivo.
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Registered trials
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