ReviewFrontiers in neuroendocrinology2009
Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease.
Review in Frontiers in neuroendocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- Associations of vitamin D receptor polymorphisms with risk of Alzheimer's disease, Parkinson's disease, and mild cognitive impairment: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2024Pooled it
- Investigating the Effect of High-Dose Vitamin D3 Administration on Inflammatory Biomarkers in Patients with Moderate to Severe Traumatic Brain Injury: A Randomized Clinical Trial.Iranian journal of medical sciences · 2024Trial
- Neuroprotective Role of Oral Vitamin D Supplementation on Consciousness and Inflammatory Biomarkers in Determining Severity Outcome in Acute Traumatic Brain Injury Patients: A Double-Blind Randomized Clinical Trial.Clinical drug investigation · 2020Trial
- Trial
- Research progress on biomarkers of traumatic brain injury.Animal models and experimental medicine · 2026Review
- Vitamin D Deficiency Does Not Affect Cognition and Neurogenesis in Adult C57Bl/6 Mice.Nutrients · 2024Article
- The mutual effect of progesterone and vitamin D in an animal model of peripheral nerve injury.Research in pharmaceutical sciences · 2024Article
- Effect of High-dose Vitamin D on IL-1β Blood Level in Patients with Moderate Stroke: A Randomized Clinical Trial.Anesthesiology and pain medicine · 2023Article
- Brain Trauma and the Secondary Cascade in Humans: Review of the Potential Role of Vitamins in Reparative Processes and Functional Outcome.Behavioral sciences (Basel, Switzerland) · 2023Review
- Clinical Study of Progesterone Combined with Vitamin B6 in the Treatment of Amenorrhea Endocrine Disorders Caused by Antipsychotics.Computational and mathematical methods in medicine · 2022Article
- Stroke-Induced Peripheral Immune Dysfunction in Vitamin D-Deficient Conditions: Modulation by Progesterone and Vitamin D.Molecular neurobiology · 2021Article
- The effect of dietary supplementation with high- or low-dose omega-3 fatty acid on inflammatory pathology after traumatic brain injury in rats.Translational neuroscience · 2021Article
- Benefits of vitamin D supplementation to attenuate TBI secondary injury?Translational neuroscience · 2021Review
- Neuroprotective effect of paricalcitol in a rat model of transient global cerebral ischemia.International journal of emergency medicine · 2020Article
- Effects of Vitamin D Use on Outcomes of Psychotic Symptoms in Alzheimer Disease Patients.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Article
- Progesterone, Lipoic Acid, and Sulforaphane as Promising Antioxidants for Retinal Diseases: A Review.Antioxidants (Basel, Switzerland) · 2019Review
- Focus on 1,25-Dihydroxyvitamin D3 in the Peripheral Nervous System.Frontiers in neuroscience · 2019Review
- 1,25-Dihydroxyvitamin DExperimental and molecular pathology · 2017Article
- Vitamin D Receptor Activation Influences NADPH Oxidase (NOXOxidative medicine and cellular longevity · 2017Article
- Nanocapsules with Polyelectrolyte Shell as a Platform for 1,25-dihydroxyvitamin D3 Neuroprotection: Study in Organotypic Hippocampal Slices.Neurotoxicity research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
More than two decades of pre-clinical research and two recent clinical trials have shown that progesterone (PROG) and its metabolites exert beneficial effects after traumatic brain injury (TBI) through a number of metabolic and physiological pathways that can reduce damage in many different tissues and organ systems. Emerging data on 1,25-dihydroxyvitamin D(3) (VDH), itself a steroid hormone, have begun to provide evidence that, like PROG, it too is neuroprotective, although some of its actions may involve different pathways. Both agents have high safety profiles, act on many different injury and pathological mechanisms, and are clinically relevant, easy to administer, and inexpensive. Furthermore, vitamin D deficiency is prevalent in a large segment of the population, especially the elderly and institutionalized, and can significantly affect recovery after CNS injury. The combination of PROG and VDH in pre-clinical and clinical studies is a novel and compelling approach to TBI treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.