ArticleThe Journal of pediatrics2009
Epidemiology and risk factors for thromboembolic complications of childhood nephrotic syndrome: a Midwest Pediatric Nephrology Consortium (MWPNC) study.
Article in The Journal of pediatrics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 6 of them syntheses that pooled it.
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59 citing papers in PubMed, 6 syntheses or guidelines pooled it, 154 citations in OpenAlex.
- Identification ofFrontiers in immunology · 2026Pooled it
- Incidence of thromboembolism in children with primary nephrotic syndrome: a systematic review and metaanalysis.BMC nephrology · 2023Pooled it
- Childhood nephrotic syndrome and the clinical profile of thromboembolism: a systematic review and meta-analysis.Pediatric research · 2023Pooled it
- Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome.Nature communications · 2023Pooled it
- The Italian Society for Pediatric Nephrology (SINePe) consensus document on the management of nephrotic syndrome in children: Part I - Diagnosis and treatment of the first episode and the first relapse.Italian journal of pediatrics · 2017Pooled it
- Clinical practice guideline for pediatric idiopathic nephrotic syndrome 2013: general therapy.Clinical and experimental nephrology · 2015Guideline
- Best practice guidelines for idiopathic nephrotic syndrome: recommendations versus reality.Pediatric nephrology (Berlin, Germany) · 2015Trial
- Article
- Effects of Prothrombin on Podocytopathy and Proteinuria in Glomerular Disease.Journal of the American Society of Nephrology : JASN · 2025Article
- Urokinase prophylactic anticoagulation in children with nephrotic syndrome: a multicenter retrospective cohort study.BMC nephrology · 2024Article
- Managing venous thrombosis in a pediatric patient with short bowel and congenital nephrotic syndromes: a case report emphasizing rivaroxaban level monitoring.Frontiers in pediatrics · 2024Article
- Association of circulating proprotein convertase subtilisin/kexin type 9 concentration with coagulation abnormalities in patients with primary membranous nephropathy.Renal failure · 2023Article
- Vitamin D supplementation in children and young adults with persistent proteinuria secondary to glomerular disease.Pediatric nephrology (Berlin, Germany) · 2023Article
- Analysis of 6 pediatric nephrotic syndrome cases with complications of cerebral sinovenous thrombosis and literature review.Frontiers in pediatrics · 2023Article
- Cerebral sinovenous thrombosis in children with nephrotic syndrome: systematic review and one new case.Frontiers in pediatrics · 2023Review
- Case report: cerebral venous sinus thrombosis and pulmonary embolism as the initial presentation in a child with asymptomatic primary nephrotic syndrome.Frontiers in pediatrics · 2023Article
- Thrombosis in Chronic Kidney Disease in Children.Diagnostics (Basel, Switzerland) · 2022Article
- Haemostatic profile of children with nephrotic syndrome attending University of Nigeria Teaching Hospital Ituku-Ozalla, Nigeria.BMC nephrology · 2022Article
- Comprehensive coagulation and fibrinolytic potential in the acute phase of pediatric patients with idiopathic nephrotic syndrome evaluated by whole blood-based rotational thromboelastometry.Pediatric nephrology (Berlin, Germany) · 2022Article
- Case of cerebral venous thrombosis on a patient with background of nephrotic syndrome.BMJ case reports · 2022Article
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8 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesTo identify clinical variables predictive of the risk of thromboembolism (TE), and to confirm the incidence of TE in primary and secondary childhood nephrotic syndrome (NS). STUDY
designA comprehensive chart review identified 326 children with NS from any cause evaluated between 1999 and 2006. These patients had a total of 1472.8 patient-years of follow-up. Comparison statistics, survival analysis, and logistic regression were used to define TE epidemiology and clinical risk factors.
resultsWe found that 9.2% of our cohort had experienced at least 1 TE. The overall incidence was 20.4 patients with TEs/1000 patient-years. The median time to the first TE was 70.5 days after diagnosis of NS. Deep venous thrombosis was the most common TE (76%) and was frequently associated with the use of a central venous catheter (45%). Significant independent predictors of TE included age > or = 12 years at onset of NS (P < .0001), severity of proteinuria (P < .0001), and history of TE preceding diagnosis of NS (P < .0001). Life- or limb-threatening TEs represented 23.7% of the events.
conclusionsChildren with NS should be carefully followed for TE, particularly those who are age 12 years or older, have severe proteinuria, or have a previous history of TE.
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