Trial reportBiological psychiatry2009
Reward processing after catecholamine depletion in unmedicated, remitted subjects with major depressive disorder.
Trial report in Biological psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- The ICCAM platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part B: fMRI description.Journal of psychopharmacology (Oxford, England) · 2017Pooled it
- Serotonin versus catecholamine deficiency: behavioral and neural effects of experimental depletion in remitted depression.Translational psychiatry · 2015Trial
- Dietary tyrosine/phenylalanine depletion effects on behavioral and brain signatures of human motivational processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Neural correlates of free T3 alteration after catecholamine depletion in subjects with remitted major depressive disorder and in controls.Psychopharmacology · 2014Trial
- Dopamine-related deficit in reward learning after catecholamine depletion in unmedicated, remitted subjects with bulimia nervosa.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
- Neural correlates of sleepiness induced by catecholamine depletion.Psychiatry research · 2011Trial
- Hikikomori in the urban digital era: a psychodynamic, transdiagnostic model and multimodal interventions.Current opinion in psychiatry · 2026Review
- Diminished differentiation of rewards in individuals at clinical high-risk for psychosis.European archives of psychiatry and clinical neuroscience · 2024Article
- Sympathetic Nerves Coordinate Corneal Epithelial Wound Healing by Controlling the Mobilization of Ly6Chi Monocytes From the Spleen to the Injured Cornea.Investigative ophthalmology & visual science · 2023Article
- Behavioral Response to Catecholamine Depletion in Individuals With Schizophrenia and Healthy Volunteers.Schizophrenia bulletin open · 2023Article
- Clenbuterol attenuates immune reaction to lipopolysaccharide and its relationship to anhedonia in adolescents.Brain, behavior, and immunity · 2022Article
- Are Essential Trace Elements Effective in Modulation of Mental Disorders? Update and Perspectives.Biological trace element research · 2022Review
- Assessment of Striatal Dopamine Transporter Binding in Individuals With Major Depressive Disorder: In Vivo Positron Emission Tomography and Postmortem Evidence.JAMA psychiatry · 2019Article
- Gender differences in the behavioral and subjective effects of methamphetamine in healthy humans.Psychopharmacology · 2019Article
- Article
- Neural Correlates of Impaired Reward-Effort Integration in Remitted Bulimia Nervosa.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- The influence of motherhood on neural systems for reward processing in low income, minority, young women.Psychoneuroendocrinology · 2016Article
- Investigating the underlying mechanisms of aberrant behaviors in bipolar disorder from patients to models: Rodent and human studies.Neuroscience and biobehavioral reviews · 2015Review
- Clinical, cognitive, and functional connectivity correlations of resting-state intrinsic brain activity alterations in unmedicated depression.Journal of affective disorders · 2015Article
- Dimensional psychiatry: reward dysfunction and depressive mood across psychiatric disorders.Psychopharmacology · 2015Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundWe investigated whether performance on a reward processing task differs between fully remitted patients with major depressive disorder (MDD) and healthy control subjects after catecholamine depletion.
methodsSeventeen unmedicated subjects with remitted MDD (RMDD) and 13 healthy control subjects underwent catecholamine depletion with oral alpha-methyl-para-tyrosine (AMPT) in a randomized, placebo-controlled, double-blind crossover study. The main outcome measure was the reaction time on the monetary incentive delay (MID) task.
resultsA diagnosis x drug interaction was evident (p = .001), which was attributable to an increase in reaction time across all incentive levels after AMPT in RMDD subjects (p = .001) but no significant AMPT effect on reaction time in control subjects (p = .17). There was no drug x diagnosis interaction on control tasks involving working memory or attention. In the RMDD sample the AMPT-induced depressive symptoms correlated with AMPT-induced changes in reaction time at all incentive levels of the MID task (r values = .58-.82, p < .002).
conclusionsUnder catecholamine depletion the RMDD subjects were robustly differentiated from control subjects by development of performance deficits on a reward processing task. These performance deficits correlated directly with the return of depressive symptoms after AMPT administration. The sensitivity of central reward processing systems to reductions in brain catecholamine levels thus seems to represent a trait-like marker in MDD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.