ArticleJournal of controlled release : official journal of the Controlled Release Society2009
Transepithelial transport of PEGylated anionic poly(amidoamine) dendrimers: implications for oral drug delivery.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 93 citations in OpenAlex.
- Polymeric nanocarriers in drug delivery, bioimaging, and biosensing: advances and perspectives on nanomicelles, nanogels, and dendrimers.RSC advances · 2025Review
- Retrovirus Drugs-Loaded PEGylated PAMAM for Prolonging Drug Release and Enhancing Efficiency in HIV Treatment.Polymers · 2021Article
- Metabolic and immunomodulatory control of type 1 diabetes via orally delivered bile-acid-polymer nanocarriers of insulin or rapamycin.Nature biomedical engineering · 2021Article
- Dendrimer-Functionalized Hybrid Materials Based on Silica as Novel Carriers of Bioactive Acids.Molecules (Basel, Switzerland) · 2020Article
- Polymer-drug conjugate therapeutics: advances, insights and prospects.Nature reviews. Drug discovery · 2019Review
- Polyamidoamine Nanoparticles for the Oral Administration of Antimalarial Drugs.Pharmaceutics · 2018Article
- Antimalarial Activity of Orally Administered Curcumin Incorporated in EudragitInternational journal of molecular sciences · 2018Article
- Radiation-Sensitive Dendrimer-Based Drug Delivery System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
- Effects of food-borne nanomaterials on gastrointestinal tissues and microbiota.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2018Review
- Dendrimers for Ocular Drug Delivery.Canadian journal of chemistry · 2017Article
- Fast Dissolving Dendrimer Nanofiber Mats as Alternative to Eye Drops for More Efficient Antiglaucoma Drug Delivery.ACS biomaterials science & engineering · 2017Article
- In vitro and in vivo uptake studies of PAMAM G4.5 dendrimers in breast cancer.Journal of nanobiotechnology · 2016Article
- Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution.Molecular pharmaceutics · 2016Article
- PEGylation as a strategy for improving nanoparticle-based drug and gene delivery.Advanced drug delivery reviews · 2016Review
- Time-Resolved Proteomic Visualization of Dendrimer Cellular Entry and Trafficking.Journal of the American Chemical Society · 2015Article
- Dendrimer nanocarriers for transport modulation across models of the pulmonary epithelium.Molecular pharmaceutics · 2015Article
- Oral absorption enhancement of probucol by PEGylated G5 PAMAM dendrimer modified nanoliposomes.Molecular pharmaceutics · 2015Article
- Predicting cytotoxicity of PAMAM dendrimers using molecular descriptors.Beilstein journal of nanotechnology · 2015Article
- Managing diabetes with nanomedicine: challenges and opportunities.Nature reviews. Drug discovery · 2015Review
- Intracellular Ca2+ release mediates cationic but not anionic poly(amidoamine) (PAMAM) dendrimer-induced tight junction modulation.Pharmaceutical research · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The purpose of this work was to assess the impact of PEGylation on transepithelial transport of anionic poly(amidoamine) dendrimers. Cytotoxicity, uptake and transport across Caco-2 cells of PEGylated G3.5 and G4.5 PAMAM dendrimers were studied. Methoxy polyethylene glycol (750 Da) was conjugated to carboxylic acid-terminated PAMAM dendrimers at feed ratios of 1, 2 and 4 PEG per dendrimer. Compared to the control, PEGylation of anionic dendrimers did not significantly alter cytotoxicity up to a concentration of 0.1 mM. PEGylation of G3.5 dendrimers significantly decreased cellular uptake and transepithelial transport while PEGylation of G4.5 dendrimers led to a significant increase in uptake, but also a significant decrease in transport. Dendrimer PEGylation reduced the opening of tight junctions as evidenced by confocal microscopy techniques. Modulation of the tight junctional complex correlated well with changes in PEGylated dendrimer transport and suggests that anionic dendrimers are transported primarily through the paracellular route. PEGylated dendrimers show promise in oral delivery applications where increased functionality for drug conjugation and release is desired.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.