ReviewFrontiers in neuroendocrinology2009
Neuroprotective actions of androgens on motoneurons.
Review in Frontiers in neuroendocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 75 citations in OpenAlex.
- Effects of Different Types of Exercise Training on Fine Motor Skills and Testosterone Concentration in Adolescents: A Cluster Randomized Controlled Trial.International journal of environmental research and public health · 2021Trial
- Testosterone signaling pathways for reducing neuropathic pain in a rat model of spinothalamic tract lesion.Iranian journal of basic medical sciences · 2024Article
- Is Dutasteride a Therapeutic Alternative for Amyotrophic Lateral Sclerosis?Biomedicines · 2022Review
- Nuclear hormone receptors in demyelinating diseases.Journal of neuroendocrinology · 2022Review
- Sex and Gender Considerations in Episodic Migraine.Current pain and headache reports · 2022Review
- The comparative effects of estrogen and tacrolimus on crushed sciatic nerve regeneration in male mice: functional and histopathological evaluation.Veterinary research forum : an international quarterly journal · 2022Article
- Steroid Sulfation in Neurodegenerative Diseases.Frontiers in molecular biosciences · 2022Review
- Is there any association between migraine headache and polycystic ovary syndrome (PCOS)? A review article.Molecular biology reports · 2022Review
- Female sex mitigates motor and behavioural phenotypes in TDP-43Scientific reports · 2020Article
- Androgen Therapy in Neurodegenerative Diseases.Journal of the Endocrine Society · 2020Review
- Testosterone Levels Are Decreased and Associated with Disease Duration in Male Spinocerebellar Ataxia Type 2 Patients.Cerebellum (London, England) · 2020Article
- Neuroprotective Effects on the Morphology of Somatic Motoneurons Following the Death of Neighboring Motoneurons: A Role for Microglia?Developmental neurobiology · 2019Article
- Activity-Based Physical Rehabilitation with Adjuvant Testosterone to Promote Neuromuscular Recovery after Spinal Cord Injury.International journal of molecular sciences · 2018Review
- Protective effects of gonadal hormones on spinal motoneurons following spinal cord injury.Neural regeneration research · 2018Review
- Prevalence of Relative Deficiencies in Testosterone and Vitamin B12 Among Patients Referred for Chronic Orchialgia: Implications for Management.American journal of men's health · 2018Article
- Protective Effects of Estradiol and Dihydrotestosterone following Spinal Cord Injury.Journal of neurotrauma · 2018Article
- The Role of BDNF in Peripheral Nerve Regeneration: Activity-Dependent Treatments and Val66Met.Frontiers in cellular neuroscience · 2018Review
- Neuroprotective effects of testosterone metabolites and dependency on receptor action on the morphology of somatic motoneurons following the death of neighboring motoneurons.Developmental neurobiology · 2017Article
- Sex differences in neuromuscular androgen receptor expression and sociosexual behavior in a sex changing fish.PloS one · 2017Article
- Neuroprotective Role of Steroidal Sex Hormones: An Overview.CNS neuroscience & therapeutics · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Androgens have a variety of protective and therapeutic effects in both the central and peripheral nervous systems. Here we review these effects as they related specifically to spinal and cranial motoneurons. Early in development, androgens are critical for the formation of important neuromuscular sex differences, decreasing the magnitude of normally occurring cell death in select motoneuron populations. Throughout the lifespan, androgens also protect against motoneuron death caused by axonal injury. Surviving motoneurons also display regressive changes to their neurites as a result of both direct axonal injury and loss of neighboring motoneurons. Androgen treatment enhances the ability of motoneurons to recover from these regressive changes and regenerate both axons and dendrites, restoring normal neuromuscular function. Androgens exert these protective effects by acting through a variety of molecular pathways. Recent work has begun to examine how androgen treatment can interact with other treatment strategies in promoting recovery from motoneuron injury.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.