ArticleAmerican journal of human genetics2009
Significant linkage evidence for a predisposition gene for pelvic floor disorders on chromosome 9q21.
Article in American journal of human genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Systematic review and meta-analysis of genetic association studies of pelvic organ prolapse.International urogynecology journal · 2022Pooled it
- Genetic epidemiology of pelvic organ prolapse: a systematic review.American journal of obstetrics and gynecology · 2014Pooled it
- Verification of the Chromosome Region 9q21 Association with Pelvic Organ Prolapse Using RegulomeDB Annotations.BioMed research international · 2015Trial
- Surgical management of stress urinary incontinence in women: safety, effectiveness and cost-utility of trans-obturator tape (TOT) versus tension-free vaginal tape (TVT) five years after a randomized surgical trial.BMC women's health · 2011Trial
- The bidirectional association between hemorrhoidal disease and varicose veins: a nationwide population-based cohort study.International journal of colorectal disease · 2025Article
- Genetics of Female Pelvic Organ Prolapse: Up to Date.Biomolecules · 2024Review
- Advances in molecular mechanisms of pelvic organ prolapse (Review).Experimental and therapeutic medicine · 2021Review
- Identification of pelvic organ prolapse risk susceptibility gene SNP locus in Xinjiang women.International urogynecology journal · 2020Article
- Clinical epidemiological insights into urinary incontinence.International urogynecology journal · 2017Review
- Biological findings from the PheWAS catalog: focus on connective tissue-related disorders (pelvic floor dysfunction, abdominal hernia, varicose veins and hemorrhoids).Human genetics · 2016Article
- Evidence for pelvic organ prolapse predisposition genes on chromosomes 10 and 17.American journal of obstetrics and gynecology · 2015Article
- Clinical characteristics of women with familial pelvic floor disorders.International urogynecology journal · 2015Article
- Significant evidence of linkage for a gene predisposing to colorectal cancer and multiple primary cancers on 22q11.Clinical and translational gastroenterology · 2014Article
- Phenotyping clinical disorders: lessons learned from pelvic organ prolapse.American journal of obstetrics and gynecology · 2013Article
- The familiality of pelvic organ prolapse in the Utah Population Database.International urogynecology journal · 2013Article
- Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse.American journal of obstetrics and gynecology · 2012Article
- Chromosome 2p14 is linked to susceptibility to leprosy.PloS one · 2012Article
- Identification of six loci associated with pelvic organ prolapse using genome-wide association analysis.Obstetrics and gynecology · 2011Article
- Genetics of pelvic organ prolapse: crossing the bridge between bench and bedside in urogynecologic research.International urogynecology journal · 2011Review
- High quality and quantity Genome-wide germline genotypes from FFPE normal tissue.BMC research notes · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Predisposition factors for pelvic floor disorders (PFDs), including pelvic organ prolapse (POP), stress urinary incontinence (SUI), urge urinary incontinence (UUI), and hernias, are not well understood. We assessed linkage evidence for PFDs in mostly sister pairs who received treatment for moderate-to-severe POP. We genotyped 70 affected women of European descent from 32 eligible families with at least two affected cases by using the Illumina 1 million single-nucleotide polymorphism (SNP) marker set. Parametric linkage analysis with general dominant and recessive models was performed by the Markov chain Monte Carlo linkage analysis method, MCLINK, and a set of SNPs was formed, from which those in high linkage disequilibrium were eliminated. Significant genome-wide evidence for linkage was identified on chromosome 9q21 with a HLOD score of 3.41 under a recessive model. Seventeen pedigrees (53%) had at least nominal evidence for linkage on a by-pedigree basis at this region. These results provide evidence for a predisposition gene for PFDs on chromosome 9q.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.