ReviewPulmonary pharmacology & therapeutics2009
Transcriptional regulation of cytokine function in airway smooth muscle cells.
Review in Pulmonary pharmacology & therapeutics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Midkine promotes PDGF-BB-induced proliferation, migration, and glycolysis of airway smooth muscle cells via the PI3K Akt pathway.Physiological reports · 2025Article
- Immunological factors, important players in the development of asthma.BMC immunology · 2024Review
- Transgenic overexpression of α7 integrin in smooth muscle attenuates allergen-induced airway inflammation in a murine model of asthma.FASEB bioAdvances · 2022Article
- Anti-Inflammatory Activity of 4-((1Pharmaceuticals (Basel, Switzerland) · 2021Article
- Eupatilin alleviates airway remodeling via regulating phenotype plasticity of airway smooth muscle cells.Bioscience reports · 2020Article
- Th1 cytokines TNF-α and IFN-γ promote corticosteroid resistance in developing human airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Differential regulation of cytokine and chemokine expression by MK2 and MK3 in airway smooth muscle cells.Pulmonary pharmacology & therapeutics · 2018Article
- Large-scale profiling of signalling pathways reveals an asthma specific signature in bronchial smooth muscle cells.Oncotarget · 2016Article
- Cigarette smoke-induced mitochondrial fragmentation and dysfunction in human airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Tidal stretches differently regulate the contractile and cytoskeletal elements in intact airways.PloS one · 2014Article
- Vitamin D supplementation reduces airway hyperresponsiveness and allergic airway inflammation in a murine model.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2013Article
- Targeting airway smooth muscle in airways diseases: an old concept with new twists.Expert review of respiratory medicine · 2011Review
- Isoprostanes and asthma.Biochimica et biophysica acta · 2011Review
- Does airway smooth muscle express an inflammatory phenotype in asthma?British journal of pharmacology · 2011Review
- Pro-inflammatory mechanisms of muscarinic receptor stimulation in airway smooth muscle.Respiratory research · 2010Article
- Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells.American journal of respiratory cell and molecular biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
The immuno-modulatory properties of airway smooth muscle have become of increasing importance in our understanding of the mechanisms underlying chronic inflammation and structural remodeling of the airway wall in asthma and chronic obstructive pulmonary disease (COPD). ASM cells respond to many cytokines, growth factors and lipid mediators to produce a wide array of immuno-modulatory molecules which may in turn orchestrate and perpetuate the disease process in asthma and COPD. Despite numerous studies of the cellular effects of cytokines on cultured ASM, few have identified intracellular signaling pathways by which cytokines modulate or induce these cellular responses. In this review we provide an overview of the transcriptional mechanisms as well as intracellular signaling pathways regulating cytokine functions in ASM cells. The recent discovery of toll-like receptors in ASM cells represents a significant development in our understanding of the immuno-modulatory capabilities of ASM cells. Thus, we also review emerging evidence of the inflammatory response to toll-like receptor activation in ASM cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.