ArticleMolecular and biochemical parasitology2009
Schistosomin from the snail Biomphalaria glabrata: expression studies suggest no involvement in trematode-mediated castration.
Article in Molecular and biochemical parasitology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 40 citations in OpenAlex.
- Total synthesis and structural characterization of a novel protein scaffold from the snail Biomphalaria glabrata.Protein science : a publication of the Protein Society · 2026Article
- Conkazal-M1 from the MKAVA family of conotoxins: A dual-function protease inhibitor and neuroactive peptide.Protein science : a publication of the Protein Society · 2026Article
- Conkazal-M1 from the MKAVA family of conotoxins - a dual-function protease inhibitor and neuroactive peptide.bioRxiv : the preprint server for biology · 2025Article
- Article
- Littorina snails and Microphallus trematodes: Diverse consequences of the trematode-induced metabolic shifts.Parasitology research · 2024Article
- Compatibility between snails and schistosomes: insights from new genetic resources, comparative genomics, and genetic mapping.Communications biology · 2022Article
- Size and survival of two freshwater snail species in relation to shedding of cercariae of castrating Echinostoma spp.Parasitology research · 2020Article
- Allelic variation in a single genomic region alters the hemolymph proteome in the snail Biomphalaria glabrata.Fish & shellfish immunology · 2019Article
- Transcriptomic responses of Biomphalaria pfeifferi to Schistosoma mansoni: Investigation of a neglected African snail that supports more S. mansoni transmission than any other snail species.PLoS neglected tropical diseases · 2017Article
- A Shift from Cellular to Humoral Responses Contributes to Innate Immune Memory in the Vector Snail Biomphalaria glabrata.PLoS pathogens · 2016Article
- Marked changes in neuropeptide expression accompany broadcast spawnings in the gastropod Haliotis asinina.Frontiers in zoology · 2012Article
- Identification and characterization of five transcription factors that are associated with evolutionarily conserved immune signaling pathways in the schistosome-transmitting snail Biomphalaria glabrata.Molecular immunology · 2011Article
- Neuro-endocrine control of reproduction in hermaphroditic freshwater snails: mechanisms and evolution.Frontiers in behavioral neuroscience · 2010Article
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5 authors at 1 institution in 1 country.
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Abstract
By inhibiting reproductive hormones, the neuropeptide schistosomin produced by the snail Lymnaea stagnalis plays an essential role in parasitic castration mediated by the schistosome parasite Trichobilharzia ocellata during late stage infection. Here we report on the presence and expression of schistosomin in the snail Biomphalaria glabrata, a prominent intermediate host of the parasite Schistosoma mansoni, one of the causative agents of human schistosomiasis. The deduced amino acid (aa) sequences from complementary DNAs (cDNAs) from B. glabrata contain a 17 aa signal peptide and a 79 aa mature peptide with 62 -- 64% identity to schistosomin from L. stagnalis. Ontogenic expression at the protein and mRNA levels showed that schistosomin was in higher abundance in embryos and juveniles relative to mature snails, suggesting that schistosomin is likely involved in developmental processes, not in reproduction. Moreover, expression data demonstrated that infection with two different digenetic trematodes, S. mansoni and Echinostoma paraensei, did not provoke elevated expression of schistosomin in B. glabrata from early stage infection (4 days post-exposure; dpe) to patent infection (up to 60dpe), by which time parasitic castration has been accomplished. In conclusion, our data suggest that a role of schistosomin in parasitic castration cannot be established in B. glabrata infected with either of two trematode species.
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