ArticleBMC genomics2009
Genomic organization and classification of the bovine WC1 genes and expression by peripheral blood gamma delta T cells.
Article in BMC genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 55 citations in OpenAlex.
- Transcriptional Profiling of Abomasal Mucosa from Young Calves Experimentally Infected withInternational journal of molecular sciences · 2025Article
- Insights into trait-association of selection signatures and adaptive eQTL in indigenous African cattle.BMC genomics · 2024Article
- Defining the caprine γδ T cell WC1 multigenic array and evaluation of its expressed sequences and gene structure conservation among goat breeds and relative to cattle.Immunogenetics · 2022Article
- Identification of Leptospiral Protein Antigens Recognized by WC1Infection and immunity · 2022Article
- The WC1 γδ T cell pathogen receptor of ruminants is preserved in the genome of ancient extinct auroch.Immunogenetics · 2021Article
- Gamma Delta TCR and the WC1 Co-Receptor Interactions in Response toFrontiers in immunology · 2021Article
- Blood transcriptome profile induced by an efficacious vaccine formulated with salivary antigens from cattle ticks.NPJ vaccines · 2019Article
- Genomic predictions combining SNP markers and copy number variations in Nellore cattle.BMC genomics · 2018Article
- Variegated Transcription of the WC1 Hybrid PRR/Co-Receptor Genes by Individual γδ T Cells and Correlation With Pathogen Responsiveness.Frontiers in immunology · 2018Article
- A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Genomic analysis of stayability in Nellore cattle.PloS one · 2017Article
- Spectratype analysis of the T cell receptor δ CDR3 region of bovine γδ T cells responding to leptospira.Immunogenetics · 2015Article
- Signal transduction by different forms of the γδ T cell-specific pattern recognition receptor WC1.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Bovine γδ T cells are a major regulatory T cell subset.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- The challenges and importance of structural variation detection in livestock.Frontiers in genetics · 2014Review
- Cell mediated innate responses of cattle and swine are diverse during foot-and-mouth disease virus (FMDV) infection: a unique landscape of innate immunity.Immunology letters · 2013Review
- Gene number determination and genetic polymorphism of the gamma delta T cell co-receptor WC1 genes.BMC genetics · 2012Article
- Evolution of the CD163 family and its relationship to the bovine gamma delta T cell co-receptor WC1.BMC evolutionary biology · 2010Article
- Analysis of copy number variations among diverse cattle breeds.Genome research · 2010Article
- Analysis of recent segmental duplications in the bovine genome.BMC genomics · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWC1 co-receptors are group B scavenger receptor cysteine-rich molecules that are found exclusively on gammadeltaT cells and are thought to be encoded by a multi-gene family. Previous studies have shown gammadeltaT cells that respond to a particular stimulus have unique WC1 molecules expressed. Prior to the onset of the studies described here only one full-length WC1 nucleotide sequence was publicly available, though three WC1 molecules had been distinguished based on monoclonal antibody reactivity. Furthermore, the number of WC1 genes found in the bovine genome and their sequences had not yet been resolved.
resultsBy annotating the bovine genome Btau_3.1 assembly, here we show the existence of 13 members in the WC1 gene family and their organization within two loci on chromosome 5 including three distinct exon-intron gene structures one of which coded for a potentially more primitive and smaller WC1 molecule that is similar to the swine WC1 gene. We also provide cDNA evidence as verification for many of the annotated sequences and show transcripts for isoforms derived by alternative splicing.
conclusionIt is possible that WC1 diversity contributes to functional differences that have been observed between gammadeltaT cell populations. The studies described here demonstrate that WC1 molecules are encoded by a large, multi-gene family whose transcripts undergo extensive alternative splicing. Similar to other non-rearranging immunoreceptors, it is likely that the WC1 gene repertoire underwent expansion in order to keep pace with rapidly changing ligands.
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