ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2009
Two different homing pathways involving integrin β7 and E-selectin significantly influence trafficking of CD4 cells to the genital tract following Chlamydia muridarum infection.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Tecovirimat for the treatment of severe Mpox in Germany.Infection · 2023Article
- IL-7-Adjuvanted Vaginal Vaccine Elicits Strong Mucosal Immune Responses in Non-Human Primates.Frontiers in immunology · 2021Article
- Vaccination with the recombinant major outer membrane protein elicits long-term protection in mice against vaginal shedding and infertility following aNPJ vaccines · 2020Article
- Effect of Time of Day of Infection on Chlamydia Infectivity and Pathogenesis.Scientific reports · 2019Article
- TLR3 Deficiency Leads to a Dysregulation in the Global Gene-Expression Profile in Murine Oviduct Epithelial Cells Infected withInternational journal of microbiology and current research · 2019Article
- T Cells in the Female Reproductive Tract Can Both Block and Facilitate HIV Transmission.Current immunology reviews · 2019Article
- Article
- South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on α4β7 for replication.Retrovirology · 2015Article
- Integrin α4β1 is necessary for CD4+ T cell-mediated protection against genital Chlamydia trachomatis infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Genital Chlamydia trachomatis: understanding the roles of innate and adaptive immunity in vaccine research.Clinical microbiology reviews · 2014Review
- Mucosal vaccines: novel strategies and applications for the control of pathogens and tumors at mucosal sites.Human vaccines & immunotherapeutics · 2014Review
- The frequency of α₄β₇(high) memory CD4⁺ T cells correlates with susceptibility to rectal simian immunodeficiency virus infection.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice.Mucosal immunology · 2013Article
- CD4+ T cells are necessary and sufficient to confer protection against Chlamydia trachomatis infection in the murine upper genital tract.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Unique features of antiviral immune system of the vaginal mucosa.Current opinion in immunology · 2012Review
- What is the influence of vaccination's routes on the regression of tumors located at mucosal sites?Oncoimmunology · 2012Article
- The genotype of early-transmitting HIV gp120s promotes α (4) β(7)-reactivity, revealing α (4) β(7) +/CD4+ T cells as key targets in mucosal transmission.PLoS pathogens · 2011Article
- Article
- The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
problemChlamydia trachomatis causes STI and reproductive dysfunction worldwide which is not preventable with antibiotics. Identifying a population of endocervical T cells to target in vaccine development would enhance efficacy. METHOD OF STUDY: Trafficking of murine CD4+ lymphocytes to Chlamydia muridarum infected genital tract (GT) tissue in vivo was measured using adoptive transfer studies of fluorescent CD4+ T cells from integrin β7-/- mice or mice which lack E-selectin on endothelial cells.
resultsMurine in vivo migration studies showed that lack of α4β7 or E-selectin significantly reduced trafficking of CD4 T cells to the GT of mice infected with C. muridarum.
conclusionCD4+ T cells use at least two different adhesive mechanisms involving an integrin of the mucosal homing pathway and selectin pathway to accumulate in the GT during C. muridarum infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.