ArticleJournal of the American Geriatrics Society2009
Treatment practices of mild cognitive impairment in California Alzheimer's Disease Centers.
Article in Journal of the American Geriatrics Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Oral Chinese herbal medicine combined with donepezil for mild cognitive impairment: A systematic review and meta-analysis.Journal of the American Geriatrics Society · 2024Pooled it
- Treatment with cholinesterase inhibitors and memantine of patients in the Alzheimer's Disease Neuroimaging Initiative.Archives of neurology · 2011Trial
- Walking stabilizes cognitive functioning in Alzheimer's disease (AD) across one year.Archives of gerontology and geriatricsTrial
- Identification of profiles associated with conversions between the Alzheimer's disease stages, using a machine learning approach.Alzheimer's research & therapy · 2024Article
- [Diagnostic procedures in patients with mild cognitive impairment and in patients with dementia].Der Nervenarzt · 2020Article
- Morphological Biomarker Differentiating MCI Converters from Nonconverters: Longitudinal Evidence Based on Hemispheric Asymmetry.Behavioural neurology · 2018Article
- Treatment of Mild Cognitive Impairment.Current treatment options in neurology · 2015Article
- Donepezil treatment in ethnically diverse patients with Alzheimer disease.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2015Observational
- Recruitment methods for United States Alzheimer disease prevention trials.The journal of nutrition, health & aging · 2012Review
- Mild cognitive impairment in clinical care: a survey of American Academy of Neurology members.Neurology · 2010Article
- Potentially inappropriate medication use in older adults with mild cognitive impairment.The journals of gerontology. Series A, Biological sciences and medical sciences · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectivesTo examine "real world" treatments for patients with mild cognitive impairment (MCI).
designCross-sectional.
settingCalifornia Department of Public Health Alzheimer's Disease (AD) Research Centers of California.
participantsFive hundred seventy-eight patients diagnosed with MCI. MEASUREMENTS: All patients underwent comprehensive neurological and neuropsychological evaluations. Logistic regression models were used to determine patient characteristics associated with use of anti-AD medications, statins, antioxidants, and folic acid.
resultsOne hundred sixty-six patients (28.7%) were taking anti-AD medications; use was associated with greater functional impairment, higher education, MCI subtype, and older age (P<.05 for all). Two hundred fifty-two patients (43.6%) were taking statins; use was associated with diabetes mellitus, hypertension, myocardial infarct, male sex, and MCI subtype (P<.05 for all). One hundred fifteen patients (19.9%) were taking antioxidants; use was associated with higher education and diabetes mellitus and varied according to site (P<.05 for all). Thirty-seven patients (6.4%) were taking folic acid; use was associated with nonwhite race, male sex, and greater functional impairment (P<.05 for all).
conclusionThis study suggests that patients with MCI are frequently being treated with "off label" cholinesterase inhibitors and memantine, as well as other possible cognition-enhancing drugs. Further investigation of the effect of treatment patterns on the clinical course of MCI is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.