ReviewMolecular and cellular biochemistry2009
The Nm23-H1-h-Prune complex in cellular physiology: a 'tip of the iceberg' protein network perspective.
Review in Molecular and cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Inorganic Polyphosphate and Human Diseases.Progress in molecular and subcellular biology · 2026Review
- Inorganic Polyphosphate Triggers NLRP3 Inflammasome and Promotes the Epithelial-to-Mesenchymal Transition and Migration of Colorectal Cancer Cells Through TRPM8 Receptor.International journal of molecular sciences · 2025Article
- Inorganic Polyphosphate Promotes Colorectal Cancer Growth via TRPM8 Receptor Signaling Pathway.Cancers · 2024Article
- Functional Genomics of PRUNE1 in Neurodevelopmental Disorders (NDDs) Tied to Medulloblastoma (MB) and Other Tumors.Frontiers in oncology · 2021Review
- Molecular markers and potential therapeutic targets in non-WNT/non-SHH (group 3 and group 4) medulloblastomas.Journal of hematology & oncology · 2019Review
- A competitive cell-permeable peptide impairs Nme-1 (NDPK-A) and Prune-1 interaction: therapeutic applications in cancer.Laboratory investigation; a journal of technical methods and pathology · 2018Review
- Epigenetic suppression of human telomerase (The Journal of biological chemistry · 2017Article
- PRUNE is crucial for normal brain development and mutated in microcephaly with neurodevelopmental impairment.Brain : a journal of neurology · 2017Article
- Inorganic polyphosphate promotes cyclin D1 synthesis through activation of mTOR/Wnt/β-catenin signaling in endothelial cells.Journal of thrombosis and haemostasis : JTH · 2016Article
- PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- 2013 scientific sessions Sol Sherry distinguished lecture in thrombosis: polyphosphate: a novel modulator of hemostasis and thrombosis.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Progress on Nme (NDP kinase/Nm23/Awd) gene family-related functions derived from animal model systems: studies on development, cardiovascular disease, and cancer metastasis exemplified.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
- A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
- Polyphosphate: a new player in the field of hemostasis.Current opinion in hematology · 2014Review
- gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins.International journal of nanomedicine · 2013Article
- Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue.Clinical proteomics · 2012Article
- Review
- Protein-protein interactions: a mechanism regulating the anti-metastatic properties of Nm23-H1.Naunyn-Schmiedeberg's archives of pharmacology · 2011Review
- Correlation of NM23-H1 cytoplasmic expression with metastatic stage in human prostate cancer tissue.Naunyn-Schmiedeberg's archives of pharmacology · 2011Article
- Metastasis suppressor function of NM23-H1 requires its 3'-5' exonuclease activity.International journal of cancer · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nm23-H1 (also known as NDPKA) and h-Prune form a protein complex that is part of a little-understood protein network. Modifications of this complex correlate with cancer status. Here, we focus on the role of the Nm23-H1-h-Prune complex in cellular physiology, through an analysis of the balance between the 'bound' and 'non-bound' states of Nm23-H1 and h-Prune, whereby we speculate on the 'read-out' during cell homeostasis under non-balanced conditions. We have analysed the biochemical activities of both Nm23-H1 and h-Prune alone and in combination, focussing on the anti-metastatic activity of Nm23-H1. We have then investigated the cellular mechanisms responsible for the formation of the Nm23-H1-h-Prune complex. To evaluate the importance of the equilibrium between the formation of the Nm23-H1-h-Prune complex and the 'free' levels of Nm23-H1 and h-Prune, we propose a model based on a pro-cancer condition where this equilibrium is negatively affected.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.