ArticlePloS one2009
Non-invasive imaging of acute renal allograft rejection in rats using small animal F-FDG-PET.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- [European journal of nuclear medicine and molecular imaging · 2021Article
- Non-invasive molecular imaging of kidney diseases.Nature reviews. Nephrology · 2021Review
- Imaging alloreactive T cells provides early warning of organ transplant rejection.JCI insight · 2021Article
- Update on imaging-based diagnosis of acute renal allograft rejection.American journal of nuclear medicine and molecular imaging · 2019Review
- Have we forgotten imaging prior to and after kidney transplantation?European radiology · 2018Article
- GC/MS-based urine metabolomics analysis of renal allograft recipients with acute rejection.Journal of translational medicine · 2018Article
- Non-invasive approaches in the diagnosis of acute rejection in kidney transplant recipients. Part I.Clinical kidney journal · 2017Review
- Novel application of complementary imaging techniques to examine in vivo glucose metabolism in the kidney.American journal of physiology. Renal physiology · 2016Article
- Imaging-based diagnosis of acute renal allograft rejection.World journal of transplantation · 2016Review
- Noninvasive monitoring of mouse renal allograft rejection using micro-CT.Annals of surgical treatment and research · 2015Article
- Renal relevant radiology: imaging in kidney transplantation.Clinical journal of the American Society of Nephrology : CJASN · 2014Review
- SPECT- and PET-based approaches for noninvasive diagnosis of acute renal allograft rejection.BioMed research international · 2014Review
- Non-invasive imaging of acute allograft rejection after rat renal transplantation using 18F-FDG PET.Journal of visualized experiments : JoVE · 2013Article
- Article
- Physiological biomarkers of acute kidney injury: a conceptual approach to improving outcomes.Contributions to nephrology · 2013Article
- Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors.Cell cycle (Georgetown, Tex.) · 2011Article
- Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis: the seed and soil also needs "fertilizer".Cell cycle (Georgetown, Tex.) · 2011Article
- Hydroxyfasudil-mediated inhibition of ROCK1 and ROCK2 improves kidney function in rat renal acute ischemia-reperfusion injury.PloS one · 2011Article
- Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAt present, renal grafts are the most common solid organ transplants world-wide. Given the importance of renal transplantation and the limitation of available donor kidneys, detailed analysis of factors that affect transplant survival are important. Despite the introduction of new and effective immunosuppressive drugs, acute cellular graft rejection (AR) is still a major risk for graft survival. Nowadays, AR can only be definitively by renal biopsy. However, biopsies carry a risk of renal transplant injury and loss. Most important, they can not be performed in patients taking anticoagulant drugs. METHODOLOGY/PRINCIPAL
findingsWe present a non-invasive, entirely image-based method to assess AR in an allogeneic rat renal transplantation model using small animal positron emission tomography (PET) and (18)F-fluorodeoxyglucose (FDG). 3 h after i.v. injection of 30 MBq FDG into adult uni-nephrectomized, allogeneically transplanted rats, tissue radioactivity of renal parenchyma was assessed in vivo by a small animal PET-scanner (post operative day (POD) 1,2,4, and 7) and post mortem dissection. The mean radioactivity (cps/mm(3) tissue) as well as the percent injected dose (%ID) was compared between graft and native reference kidney. Results were confirmed by histological and autoradiographic analysis. Healthy rats, rats with acute CSA nephrotoxicity, with acute tubular necrosis, and syngeneically transplanted rats served as controls. FDG-uptake was significantly elevated only in allogeneic grafts from POD 1 on when compared to the native kidney (%ID graft POD 1: 0.54+/-0.06; POD 2: 0.58+/-0.12; POD 4: 0.81+/-0.06; POD 7: 0.77+/-0.1; CTR: 0.22+/-0.01, n = 3-28). Renal FDG-uptake in vivo correlated with the results obtained by micro-autoradiography and the degree of inflammatory infiltrates observed in histology. CONCLUSIONS/SIGNIFICANCE: We propose that graft FDG-PET imaging is a new option to non-invasively, specifically, early detect, and follow-up acute renal rejection. This method is potentially useful to improve post-transplant rejection monitoring.
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