ArticlePloS one2009
Transcriptional network of p63 in human keratinocytes.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- GOF Mutant p53 in Cancers: A Therapeutic Challenge.Cancers · 2022Review
- A combination of cytokeratin 5/6, p63, p40 and MUC5AC are useful for distinguishing squamous cell carcinoma from adenocarcinoma of the cervix.Diagnostic pathology · 2020Article
- Ectrodactyly-ectodermal dysplasia-clefting syndrome with unusual cutaneous vitiligoid and psoriasiform lesions due to a novel single pointPostepy dermatologii i alergologii · 2019Article
- p63 establishes epithelial enhancers at critical craniofacial development genes.Science advances · 2019Article
- Learning from regeneration research organisms: The circuitous road to scar free wound healing.Developmental biology · 2018Review
- Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines.Head & neck · 2017Article
- Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma.Molecular cancer research : MCR · 2016Article
- FGF8, c-Abl and p300 participate in a pathway that controls stability and function of the ΔNp63α protein.Human molecular genetics · 2015Article
- Wilms' tumor gene 1 regulates p63 and promotes cell proliferation in squamous cell carcinoma of the head and neck.BMC cancer · 2015Article
- The wind rose of human keratinocyte cell fate.Cellular and molecular life sciences : CMLS · 2014Article
- Role of chromatin and transcriptional co-regulators in mediating p63-genome interactions in keratinocytes.BMC genomics · 2014Article
- 3D In vitro model of a functional epidermal permeability barrier from human embryonic stem cells and induced pluripotent stem cells.Stem cell reports · 2014Article
- Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia.EMBO molecular medicine · 2013Review
- Functional interplay between p63 and p53 controls RUNX1 function in the transition from proliferation to differentiation in human keratinocytes.Cell death & disease · 2012Article
- p63 regulates human keratinocyte proliferation via MYC-regulated gene network and differentiation commitment through cell adhesion-related gene network.The Journal of biological chemistry · 2012Article
- Regulation of skin aging and heart development by TAp63.Cell death and differentiation · 2012Review
- The miR-17 family links p63 protein to MAPK signaling to promote the onset of human keratinocyte differentiation.PloS one · 2012Article
- Analysis of large phenotypic variability of EEC and SHFM4 syndromes caused by K193E mutation of the TP63 gene.PloS one · 2012Article
- p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis.The Journal of cell biology · 2011Article
- Large scale RNAi screen reveals that the inhibitor of DNA binding 2 (ID2) protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation.The Journal of biological chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
p63 is a transcription factor required for the development and maintenance of ectodermal tissues in general, and skin keratinocytes in particular. The identification of its target genes is fundamental for understanding the complex network of gene regulation governing the development of epithelia. We report a list of almost 1000 targets derived from ChIP on chip analysis on two platforms; all genes analyzed changed in expression during differentiation of human keratinocytes. Functional annotation highlighted unexpected GO terms enrichments and confirmed that genes involved in transcriptional regulation are the most significant. A detailed analysis of these transcriptional regulators in condition of perturbed p63 levels confirmed the role of p63 in the regulatory network. Rather than a rigid master-slave hierarchical model, our data indicate that p63 connects different hubs involved in the multiple specific functions of the skin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.