ArticleFrontiers in systems neuroscience2009
Pausing purkinje cells in the cerebellum of the awake cat.
Article in Frontiers in systems neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 66 citations in OpenAlex.
- Purkinje cell models: past, present and future.Frontiers in computational neuroscience · 2024Review
- Neuronal activity patterns in microcircuits of the cerebellar cortical C3 zone during reaching.The Journal of physiology · 2022Article
- Gating by Memory: a Theory of Learning in the Cerebellum.Cerebellum (London, England) · 2022Article
- Radiofrequency electromagnetic field affects heart rate variability in rabbits.Physiological research · 2020Article
- The Role of BTBD9 in the Cerebellum, Sleep-like Behaviors and the Restless Legs Syndrome.Neuroscience · 2020Article
- Neural Signals in Red Nucleus during Reactive and Proactive Adjustments in Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Functional Alteration of Cerebello-Cerebral Coupling in an Experimental Mouse Model of Parkinson's Disease.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Online Detection of Multiple Stimulus Changes Based on Single Neuron Interspike Intervals.Frontiers in computational neuroscience · 2019Article
- Complex Spike Wars: a New Hope.Cerebellum (London, England) · 2018Review
- Cerebellar learning using perturbations.eLife · 2018Article
- Switching in Feedforward Control of Grip Force During Tool-Mediated Interaction With Elastic Force Fields.Frontiers in neurorobotics · 2018Article
- Long Pauses in Cerebellar Interneurons in Anesthetized Animals.Cerebellum (London, England) · 2017Article
- Climbing Fibers Control Purkinje Cell Representations of Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Power Spectral Density Analysis of Purkinje Cell Tonic and Burst Firing Patterns From a Rat Model of Ataxia and Riluzole Treated.Basic and clinical neuroscience · 2017Article
- Inverse Stochastic Resonance in Cerebellar Purkinje Cells.PLoS computational biology · 2016Article
- Article
- Determinants of rebound burst responses in rat cerebellar nuclear neurons to physiological stimuli.The Journal of physiology · 2016Article
- In vivo differences in inputs and spiking between neurons in lobules VI/VII of neocerebellum and lobule X of archaeocerebellum.Cerebellum (London, England) · 2015Article
- Article
- Spinocerebellar ataxia type 6 protein aggregates cause deficits in motor learning and cerebellar plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A recent controversy has emerged concerning the existence of long pauses, presumably reflecting bistability of membrane potential, in the cerebellar Purkinje cells (PC) of awake animals. It is generally agreed that in the anesthetized animals and in vitro, these cells switch between two stable membrane potential states: a depolarized state (the 'up-state') characterized by continuous firing of simple spikes (SS) and a hyperpolarized state (the 'down-state') characterized by long pauses in the SS activity. To address the existence of long pauses in the neural activity of cerebellar PCs in the awake and behaving animal we used extracellular recordings in cats and find that approximately half of the recorded PCs exhibit such long pauses in the SS activity and transition between activity - periods with uninterrupted SS lasting an average of 1300 ms - and pauses up to several seconds. We called these cells pausing Purkinje cells (PPC) and they can easily be distinguished from continuous firing Purkinje cells. In most PPCs, state transitions in both directions were often associated (25% of state transitions) with complex spikes (CSs). This is consistent with intracellular findings of CS-driven state transitions. In sum, we present proof for the existence of long pauses in the PC SS activity that probably reflect underlying bistability, provide the first in-depth analysis of these pauses and show for the first time that transitions in and out of these pauses are related to CS firing in the awake and behaving animal.
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