ArticlePloS one2009
Integron gene cassettes and degradation of compounds associated with industrial waste: the case of the Sydney tar ponds.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Identification of virulence genes and clade-specific markers through pan-genomic analysis of Leptospira.BMC microbiology · 2025Article
- Discovery of integrons in Archaea: Platforms for cross-domain gene transfer.Science advances · 2022Article
- Methods for the targeted sequencing and analysis of integrons and their gene cassettes from complex microbial communities.Microbial genomics · 2022Article
- Biochar and Manure Applications Differentially Altered the Class 1 Integrons, Antimicrobial Resistance, and Gene Cassettes Diversity in Paddy Soils.Frontiers in microbiology · 2022Article
- The Natural History of Integrons.Microorganisms · 2021Review
- Evaluating the Potential Antibiotic Resistance Status in Environment Based on the Trait of Microbial Community.Frontiers in microbiology · 2020Article
- Promoter activity of ORF-less gene cassettes isolated from the oral metagenome.Scientific reports · 2019Article
- Discovery of the fourth mobile sulfonamide resistance gene.Microbiome · 2017Article
- The antimicrobial resistance crisis: management through gene monitoring.Open biology · 2016Article
- Diversity of gene cassettes and the abundance of the class 1 integron-integrase gene in sediment polluted by metals.Extremophiles : life under extreme conditions · 2016Article
- Article
- Integron diversity in marine environments.Environmental science and pollution research international · 2015Review
- Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution.The ISME journal · 2015Review
- Integrons: past, present, and future.Microbiology and molecular biology reviews : MMBR · 2014Review
- The function of integron-associated gene cassettes in Vibrio species: the tip of the iceberg.Frontiers in microbiology · 2013Review
- Integron involvement in environmental spread of antibiotic resistance.Frontiers in microbiology · 2012Article
- Impacts of anthropogenic activity on the ecology of class 1 integrons and integron-associated genes in the environment.The ISME journal · 2011Article
- Marine integrons containing novel integrase genes, attachment sites, attI, and associated gene cassettes in polluted sediments from Suez and Tokyo Bays.The ISME journal · 2011Article
- The influence of the accessory genome on bacterial pathogen evolution.Mobile genetic elements · 2011Article
- Short clones or long clones? A simulation study on the use of paired reads in metagenomics.BMC bioinformatics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integrons are genetic platforms that accelerate lateral gene transfer (LGT) among bacteria. They were first detected on plasmids bearing single and multiple drug resistance determinants in human pathogens, and it is abundantly clear that integrons have played a major role in the evolution of this public health menace. Similar genetic elements can be found in nonpathogenic environmental bacteria and in metagenomic environmental DNA samples, and it is reasonable to suppose that integrons have facilitated microbial adaptation through LGT in niches outside infectious disease wards. Here we show that a heavily impacted estuary, exposed for almost a century to products of coal and steel industries, has developed a rich and unique cassette metagenome, containing genes likely to aid in the catabolism of compounds associated with industrial waste found there. In addition, we report that the most abundant cassette recovered in this study is one that encodes a putative LysR protein. This autoregulatory transcriptional regulator is known to activate transcription of linked target genes or unlinked regulons encoding diverse functions including chlorocatechol and dichlorophenol catabolism. Finally, only class 1 integrase genes were amplified in this study despite using different primer sets, and it may be that the cassettes present in the Tar Ponds will prove to be associated with class 1 integrase genes. Nevertheless, our cassette library provides a snapshot of a complex evolutionary process involving integron-meditated LGT likely to be important in natural bioremediation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.