Evidence map›Paper›PMID 19390049›Full record

ArticleScience (New York, N.Y.)2009

The genome sequence of taurine cattle: a window to ruminant biology and evolution.

Bovine Genome Sequencing and Analysis Consortium, Christine G Elsik, Ross L Tellam, Kim C Worley, Richard A Gibbs, Donna M Muzny, George M Weinstock, David L Adelson, Evan E Eichler, Laura Elnitski and 298 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 565 papers.

0numbers the graph read from it
0cells of the map it votes in
565citing papers in PubMed
72.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

565 citing papers in PubMed, 1,331 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Advances in Molecular Genetics and Breeding of Cattle, Sheep, and Goats.Animals : an open access journal from MDPI · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. The chromosome-level genome of Chinese indicine cattle breed provides insights into bovine adaptation and immunity.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Genome assemblies of IndianNAR genomics and bioinformatics · 2025
    Article
  20. Review

505 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

308 authors at 1 institution in 1 country.

Bovine Genome Sequencing and Analysis Consortium
Christine G Elsik
Ross L Tellam
Kim C Worley
Richard A Gibbs
Donna M Muzny
George M Weinstock
David L Adelson
Evan E Eichler
Laura Elnitski
Roderic Guigó
Debora L Hamernik
Steve M Kappes
Harris A Lewin
David J Lynn
Frank W Nicholas
Alexandre Reymond
Monique Rijnkels
Loren C Skow
Evgeny M Zdobnov
Lawrence Schook
James Womack
Tyler Alioto
Stylianos E Antonarakis
Alex Astashyn
Charles E Chapple
Hsiu-Chuan Chen
Jacqueline Chrast
Francisco Câmara
Olga Ermolaeva
Charlotte N Henrichsen
Wratko Hlavina
Yuri Kapustin
Boris Kiryutin
Paul Kitts
Felix Kokocinski
Melissa Landrum
Donna Maglott
Kim Pruitt
Victor Sapojnikov
Stephen M Searle
Victor Solovyev
Alexandre Souvorov
Catherine Ucla
Carine Wyss
Juan M Anzola
Daniel Gerlach
Eran Elhaik
Dan Graur
Justin T Reese
Robert C Edgar
John C McEwan
Gemma M Payne
Joy M Raison
Thomas Junier
Evgenia V Kriventseva
Eduardo Eyras
Mireya Plass
Ravikiran Donthu
Denis M Larkin
James Reecy
Mary Q Yang
Lin Chen
Ze Cheng
Carol G Chitko-McKown
George E Liu
Lakshmi K Matukumalli
Jiuzhou Song
Bin Zhu
Daniel G Bradley
Fiona S L Brinkman
Lilian P L Lau
Matthew D Whiteside
Angela Walker
Thomas T Wheeler
Theresa Casey
J Bruce German
Danielle G Lemay
Nauman J Maqbool
Adrian J Molenaar
Seongwon Seo
Paul Stothard
Cynthia L Baldwin
Rebecca Baxter
Candice L Brinkmeyer-Langford
Wendy C Brown
Christopher P Childers
Timothy Connelley
Shirley A Ellis
Krista Fritz
Elizabeth J Glass
Carolyn T A Herzig
Antti Iivanainen
Kevin K Lahmers
Anna K Bennett
C Michael Dickens
James G R Gilbert
Darren E Hagen
Hanni Salih
Jan Aerts
Alexandre R Caetano
Brian Dalrymple
Jose Fernando Garcia
Clare A Gill
Stefan G Hiendleder
Erdogan Memili
Diane Spurlock
John L Williams
Lee Alexander
Michael J Brownstein
Leluo Guan
Robert A Holt
Steven J M Jones
Marco A Marra
Richard Moore
Stephen S Moore
Andy Roberts
Masaaki Taniguchi
Richard C Waterman
Joseph Chacko
Mimi M Chandrabose
Andy Cree
Marvin Diep Dao
Huyen H Dinh
Ramatu Ayiesha Gabisi
Sandra Hines
Jennifer Hume
Shalini N Jhangiani
Vandita Joshi
Christie L Kovar
Lora R Lewis
Yih-Shin Liu
John Lopez
Margaret B Morgan
Ngoc Bich Nguyen
Geoffrey O Okwuonu
San Juana Ruiz
Jireh Santibanez
Rita A Wright
Christian Buhay
Yan Ding
Shannon Dugan-Rocha
Judith Herdandez
Michael Holder
Aniko Sabo
Amy Egan
Jason Goodell
Katarzyna Wilczek-Boney
Gerald R Fowler
Matthew Edward Hitchens
Ryan J Lozado
Charles Moen
David Steffen
James T Warren
Jingkun Zhang
Readman Chiu
Jacqueline E Schein
K James Durbin
Paul Havlak
Huaiyang Jiang
Yue Liu
Xiang Qin
Yanru Ren
Yufeng Shen
Henry Song
Stephanie Nicole Bell
Clay Davis
Angela Jolivet Johnson
Sandra Lee
Lynne V Nazareth
Bella Mayurkumar Patel
Ling-Ling Pu
Selina Vattathil
Rex Lee Williams
Stacey Curry
Cerissa Hamilton
Erica Sodergren
David A Wheeler
Wes Barris
Gary L Bennett
André Eggen
Ronnie D Green
Gregory P Harhay
Matthew Hobbs
Oliver Jann
John W Keele
Matthew P Kent
Sigbjørn Lien
Stephanie D McKay
Sean McWilliam
Abhirami Ratnakumar
Robert D Schnabel
Timothy Smith
Warren M Snelling
Tad S Sonstegard
Roger T Stone
Yoshikazu Sugimoto
Akiko Takasuga
Jeremy F Taylor
Curtis P Van Tassell
Michael D Macneil
Antonio R R Abatepaulo
Colette A Abbey
Virpi Ahola
Iassudara G Almeida
Ariel F Amadio
Elen Anatriello
Suria M Bahadue
Fernando H Biase
Clayton R Boldt
Jeffery A Carroll
Wanessa A Carvalho
Eliane P Cervelatti
Elsa Chacko
Jennifer E Chapin
Ye Cheng
Jungwoo Choi
Adam J Colley
Tatiana A de Campos
Marcos De Donato
Isabel K F de Miranda Santos
Carlo J F de Oliveira
Heather Deobald
Eve Devinoy
Kaitlin E Donohue
Peter Dovc
Annett Eberlein
Carolyn J Fitzsimmons
Alessandra M Franzin
Gustavo R Garcia
Sem Genini
Cody J Gladney
Jason R Grant
Marion L Greaser
Jonathan A Green
Darryl L Hadsell
Hatam A Hakimov
Rob Halgren
Jennifer L Harrow
Elizabeth A Hart
Nicola Hastings
Marta Hernandez
Zhi-Liang Hu
Aaron Ingham
Terhi Iso-Touru
Catherine Jamis
Kirsty Jensen
Dimos Kapetis
Tovah Kerr
Sari S Khalil
Hasan Khatib
Davood Kolbehdari
Charu G Kumar
Dinesh Kumar
Richard Leach
Justin C-M Lee
Changxi Li
Krystin M Logan
Roberto Malinverni
Elisa Marques
William F Martin
Natalia F Martins
Sandra R Maruyama
Raffaele Mazza
Kim L McLean
Juan F Medrano
Barbara T Moreno
Daniela D Moré
Carl T Muntean
Hari P Nandakumar
Marcelo F G Nogueira
Ingrid Olsaker
Sameer D Pant
Francesca Panzitta
Rosemeire C P Pastor
Mario A Poli
Nathan Poslusny
Satyanarayana Rachagani
Shoba Ranganathan
Andrej Razpet
Penny K Riggs
Gonzalo Rincon
Nelida Rodriguez-Osorio
Sandra L Rodriguez-Zas
Natasha E Romero
Anne Rosenwald
Lillian Sando
Sheila M Schmutz
Libing Shen
Laura Sherman
Bruce R Southey
Ylva Strandberg Lutzow
Jonathan V Sweedler
Imke Tammen
Bhanu Prakash V L Telugu
Jennifer M Urbanski
Yuri T Utsunomiya
Chris P Verschoor
Ashley J Waardenberg
Zhiquan Wang
Robert Ward
Rosemarie Weikard
Thomas H Welsh
Stephen N White
Laurens G Wilming
Kris R Wunderlich
Jianqi Yang
Feng-Qi Zhao
Baylor College of Medicine · US

Funding

The Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3M
Regulatory and epigenetic landscapes reveal biological processes, disease mechanisms and diagnostic markersZIAHG200323 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ELNITSKI, LAURA L · 2009 to 2025
$27.6M
The UIUC Neuroproteomics Center on Cell-Cell SignalingP30DA018310 · NIDA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Elena V Romanova · 2004 to 2026
$24.9M
Biotechnology and Biological Sciences Research Council BB/D524040/2Biotechnology and Biological Sciences Research Council BBS/B/13438Biotechnology and Biological Sciences Research Council BBS/B/13446NHGRI NIH HHS U54 HG003273NIDA NIH HHS P30 DA018310Wellcome Trust 062023Wellcome Trust 077198
6 · The paper itself

Abstract

To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.

Indexed as

Biological EvolutionGenomeAlternative SplicingAnimalsAnimals, DomesticCattleEvolution, MolecularFemaleGenetic VariationHumansMaleMicroRNAsMolecular Sequence DataProteinsSequence Analysis, DNASpecies SpecificityMicroRNAsProteins

Identifiers

PMID19390049
PMCPMC2943200
OpenAlexW2154380613

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.