ArticleDiabetes care2009
TRIB3 functional Q84R polymorphism is a risk factor for metabolic syndrome and carotid atherosclerosis.
Article in Diabetes care, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- TRIB3 Links Endoplasmic Reticulum Stress to Impaired Efferocytosis in Atherosclerosis.Circulation research · 2025Article
- Circulating TRB3 and GRP78 levels in type 2 diabetes patients: crosstalk between glucose homeostasis and endoplasmic reticulum stress.Journal of endocrinological investigation · 2022Article
- Article
- The TRIB3 R84 variant is associated with increased left ventricular mass in a sample of 2426 White individuals.Cardiovascular diabetology · 2021Observational
- Polytropic Influence ofFrontiers in pharmacology · 2019Article
- ADisease models & mechanisms · 2017Article
- Assessment of Human Tribbles Homolog 3 Genetic Variation (rs2295490) Effects on Type 2 Diabetes Patients with Glucose Control and Blood Pressure Lowering Treatment.EBioMedicine · 2016Article
- Sitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in the Zucker Diabetic Fatty rat - focus on amelioration of metabolic profile and tissue cytoprotective properties.Diabetology & metabolic syndrome · 2014Article
- ALK7 gene polymorphism is associated with metabolic syndrome risk and cardiovascular remodeling.Arquivos brasileiros de cardiologia · 2013Article
- Insulin relaxes bladder via PI3K/AKT/eNOS pathway activation in mucosa: unfolded protein response-dependent insulin resistance as a cause of obesity-associated overactive bladder.The Journal of physiology · 2013Article
- Mammalian tribbles homologs at the crossroads of endoplasmic reticulum stress and Mammalian target of rapamycin pathways.Scientifica · 2013Article
- Decreased serum obestatin consequent upon TRIB3 Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome.Diabetology & metabolic syndrome · 2012Article
- The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases.Endocrine reviews · 2012Review
- Article
- Silence of TRIB3 suppresses atherosclerosis and stabilizes plaques in diabetic ApoE-/-/LDL receptor-/- mice.Diabetes · 2012Article
- TRB3 gene silencing alleviates diabetic cardiomyopathy in a type 2 diabetic rat model.Diabetes · 2011Article
- Association of TRB3 Q84R polymorphism with polycystic ovary syndrome in Chinese women.Reproductive biology and endocrinology : RB&E · 2011Article
- Whole genome association scan for genetic polymorphisms influencing information processing speed.Biological psychology · 2011Article
- Tribbles homologue 3 (TRIB3) and the insulin-resistance genes in type 2 diabetes.Diabetologia · 2010Article
- The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells.The Journal of clinical investigation · 2010Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the association of TRIB3 Q84R polymorphism with metabolic syndrome (MetS) and carotid atherosclerosis. RESEARCH DESIGN AND
methodsA case-control study enrolled 513 Chinese subjects in three groups: control, MetS, and obese. The functional TRIB3 Q84R polymorphism was genotyped among subjects undergoing carotid ultrasonography. The clinical and biochemical characteristics were determined.
resultsFor individuals with the TRIB3 R84 allele, the odds ratio for developing MetS was 2.349 (P = 0.018), abdominal obesity 2.351 (P = 0.012), hypertriglyceridemia 2.314 (P = 0.00003), and insulin resistance 1.697 (P = 0.023). Likewise, the odds ratio for individuals with the TRIB3 R84 allele to develop thickened intima-media thickness was 2.208 (P = 0.040).
conclusionsIndividuals with the functional TRIB3 Q84R polymorphism are at risk for MetS. The TRIB3 R84 allele especially predisposes to carotid atherosclerosis in part through the effects of abdominal obesity, hypertriglyceridemia, and insulin resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.