ArticleJournal of leukocyte biology2009
Neutrophils rescue gingival epithelial cells from bacterial-induced apoptosis.
Article in Journal of leukocyte biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Reductions in clinical inflammation and oral neutrophils with improving oral hygiene.Clinical oral investigations · 2021Trial
- Does Oral Endotoxin Contribute to Systemic Inflammation?Frontiers in oral health · 2022Review
- Periodontal Pathogens' strategies disarm neutrophils to promote dysregulated inflammation.Molecular oral microbiology · 2021Review
- Three-DimensionalTissue engineering. Part B, Reviews · 2020Review
- Biofilm-stimulated epithelium modulates the inflammatory responses in co-cultured immune cells.Scientific reports · 2019Article
- Novel Assay To Characterize Neutrophil Responses to Oral Biofilms.Infection and immunity · 2019Article
- MicroRNA-663 antagonizes apoptosis antagonizing transcription factor to induce apoptosis in epithelial cells.Apoptosis : an international journal on programmed cell death · 2019Article
- FOXO1 Regulates Bacteria-Induced Neutrophil Activity.Frontiers in immunology · 2017Article
- Dynamic interactions of neutrophils and biofilms.Journal of oral microbiology · 2014Article
- LL-37 opsonizes and inhibits biofilm formation of Aggregatibacter actinomycetemcomitans at subbactericidal concentrations.Infection and immunity · 2013Article
- Neutrophils alter epithelial response to Porphyromonas gingivalis in a gingival crevice model.Molecular oral microbiology · 2013Article
- Porphyromonas gingivalis regulates TREM-1 in human polymorphonuclear neutrophils via its gingipains.PloS one · 2013Article
- Epithelial cell pro-inflammatory cytokine response differs across dental plaque bacterial species.Journal of clinical periodontology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In the pathogenesis of chronic inflammatory periodontal disease, neutrophils are recognized as a major cellular component from the histopathology of the periodontal lesion around teeth and from clinical cases where absence or dysfunction of neutrophils results in major periodontal destruction. Neutrophils are recruited in vast numbers into the gingival crevice during periodontal inflammation, attracted by microbial plaque chemoattractants and chemokines released following microbial perturbation of gingival epithelial cells. Porphyromonas gingivalis, a major periodontopathogen, triggers a vast array of cellular responses in gingival epithelial cells but also induces apoptosis. We demonstrate here that neutrophils, when combined in a P. gingivalis challenge assay of epithelial cells, prevent epithelial cell apoptosis by phagocytosing P. gingivalis and later undergoing apoptosis themselves. By removing P. gingivalis by phagocytosis, neutrophils also protect the host from the harmful effects of its microbial proteases, which degrade inflammatory cytokines and other host molecules.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.