Evidence map›Paper›PMID 19389586›Full record

ArticleImmunology and allergy clinics of North America2009

Psychoneuroimmune implications of type 2 diabetes: redux.

Jason C O'Connor, Daniel R Johnson, Gregory G Freund

Abstract read
In one paragraph

Article in Immunology and allergy clinics of North America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Jason C O'ConnorDepartment of Animal Sciences, University of Illinois, 1201 West Gregory Drive, Urbana, IL 61801, USA.
Daniel R Johnson
Gregory G Freund

Funding

Brain Immune Interactions In Type 2 DiabetesR01DK064862 · NIDDK · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI FREUND, GREGORY G · 2004 to 2013
$3.4M
Hypoxia: an activator of neuroimmunityR01NS058525 · NINDS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI FREUND, GREGORY G · 2008 to 2012
$1.6M
NIDDK NIH HHS R01 DK064862NINDS NIH HHS R01 NS058525
6 · The paper itself

Abstract

A sizable body of knowledge has arisen demonstrating that type 2 diabetes (T2D) is associated with alterations in the innate immune system. The resulting proinflammatory-leaning imbalance is implicated in the development of secondary disease complications and comorbidities, such as delayed wound healing, accelerated progress of atherosclerosis, and retinopathy, in people who have T2D. New experimental data and the results of recently published health-related quality-of-life surveys indicate that individuals who have T2D experience diminished feelings of happiness, well being, and satisfaction with life. These emotional and psychological consequences of T2D point to altered neuroimmunity as a previously unappreciated complication of T2D. This article discusses recent data detailing the impact of T2D on a person's PNI response.

Identifiers

PMID19389586
PMCPMC2739571

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.