Evidence map›Paper›PMID 19389469›Full record

ArticleBrain, behavior, and immunity2009

To assess, to control, to exclude: effects of biobehavioral factors on circulating inflammatory markers.

Mary-Frances O'Connor, Julie E Bower, Hyong Jin Cho, J David Creswell, Stoyan Dimitrov, Mary E Hamby, Michael A Hoyt, Jennifer L Martin, Theodore F Robles, Erica K Sloan and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06263452 (Beta-Blocker Influences on Inflammatory and Neural Responses to Stress), which is not on this map. Cited by 307 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
307citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06263452 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Beta-Blocker Influences on Inflammatory and Neural Responses to Stress

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2024 to 2026Enrolled120ConditionsCardiovascular DiseaseArmsPropranolol, Placebo
3 · Its place in the literature

Who cites it

307 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  20. Moderators for depressed mood and systemic and transcriptional inflammatory responses: a randomized controlled trial of endotoxin.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Trial

247 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Mary-Frances O'ConnorDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Cousins Center for Psychoneuroimmunology, Cousins Center for Psychoneuroimmunology, Los Angeles, CA 90095, USA. mfoconnor@mednet.ucla.edu
Julie E Bower
Hyong Jin Cho
J David Creswell
Stoyan Dimitrov
Mary E Hamby
Michael A Hoyt
Jennifer L Martin
Theodore F Robles
Erica K Sloan
Kamala S Thomas
Michael R Irwin

Funding

ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8M
Fellowship on Biological Psychiatry and NeuroscienceT32MH018399 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pei-an (Betty) Shih · 1986 to 2026
$7.3M
Aging: Sleep and Inflammatory Mechanisms in Depression PreventionR01AG026364 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2005 to 2015
$5.8M
Sleep and Immune Mechanisms in Rheumatoid ArthritisR01HL079955 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2009
$3.0M
Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune MechanismsR01CA119159 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2010
$2.2M
Subjective Social Isolation and Sleep Disturbances: Inflammatory Mechanisms in AgR01AG034588 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2009 to 2013
$1.9M
Post-Graduate Training Program in Psychoneuroimmunology and Mental HealthT32MH019925 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 1997 to 2012
$1.7M
Complicated Grief in Older Adults: Physiological Substrates of Emotion RegulationK01AG028404 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI O'CONNOR, MARY-FRANCES · 2007 to 2011
$681k
Sleep-related predictors of function and health among vulnerable older peopleK23AG028452 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, JENNIFER L · 2007 to 2009
$405k
NCI NIH HHS R01 CA119159NCRR NIH HHS M01 RR000865NHLBI NIH HHS R01 HL079955NIA NIH HHS K01 AG028404NIA NIH HHS K23 AG028452NIA NIH HHS P30 AG028748NIA NIH HHS R01 AG026364NIA NIH HHS R01 AG034588NIMH NIH HHS T32 MH018399NIMH NIH HHS T32 MH019925NIMH NIH HHS T32-MH19925
6 · The paper itself

Abstract

Behavioral scientists have increasingly included inflammatory biology as mechanisms in their investigation of psychosocial dynamics on the pathobiology of disease. However, a lack of standardization of inclusion and exclusion criteria and assessment of relevant control variables impacts the interpretation of these studies. The present paper reviews and discusses human biobehavioral factors that can affect the measurement of circulating markers of inflammation. Keywords relevant to inflammatory biology and biobehavioral factors were searched through PubMed. Age, sex, and hormonal status, socioeconomic status, ethnicity and race, body mass index, exercise, diet, caffeine, smoking, alcohol, sleep disruption, antidepressants, aspirin, and medications for cardiovascular disease are all reviewed. A tiered set of recommendations as to whether each variable should be assessed, controlled for, or used as an exclusion criteria is provided. These recommendations provide a framework for observational and intervention studies investigating linkages between psychosocial and behavioral factors and inflammation.

Indexed as

Anticholesteremic AgentsAntidepressive Agents, Second-GenerationAntihypertensive AgentsBiomarkersBody Mass IndexDietEpidemiologic FactorsExerciseHumansInflammationInterleukinsPatient SelectionPhysical FitnessResearch DesignRisk FactorsRisk-TakingAnticholesteremic AgentsAntidepressive Agents, Second-GenerationAntihypertensive AgentsBiomarkersInterleukinsTumor Necrosis Factor-alpha

Identifiers

PMID19389469
PMCPMC2749909

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.