ArticleDevelopmental biology2009
Unexpected functional redundancy between Twist and Slug (Snail2) and their feedback regulation of NF-kappaB via Nodal and Cerberus.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Butyrate Produced by Gut Microbiota Regulates Atherosclerosis: A Narrative Review of the Latest Findings.International journal of molecular sciences · 2025Review
- A comparative study of cellular diversity between the Xenopus pronephric and mouse metanephric nephron.Kidney international · 2023Article
- Expression atlas of avian neural crest proteins: Neurulation to migration.Developmental biology · 2022Article
- Neural crest multipotency and specification: power and limits of single cell transcriptomic approaches.Faculty reviews · 2021Review
- miR-423 Promotes Breast Cancer Invasion by Activating NF-κB Signaling.OncoTargets and therapy · 2020Article
- Specifying neural crest cells: From chromatin to morphogens and factors in between.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- Ras GTPase-Activating-Like Protein IQGAP1 (IQGAP1) Promotes Breast Cancer Proliferation and Invasion and Correlates with Poor Clinical Outcomes.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Neural crest development in Xenopus requires Protocadherin 7 at the lateral neural crest border.Mechanisms of development · 2018Article
- Twist1 mediated regulation of glioma tumorigenicity is dependent on mode of mouse neural progenitor transformation.Oncotarget · 2017Article
- Article
- Identifying domains of EFHC1 involved in ciliary localization, ciliogenesis, and the regulation of Wnt signaling.Developmental biology · 2016Article
- Loss of Snail2 favors skin tumor progression by promoting the recruitment of myeloid progenitors.Carcinogenesis · 2015Article
- Human Cerberus prevents nodal-receptor binding, inhibits nodal signaling, and suppresses nodal-mediated phenotypes.PloS one · 2015Article
- Chibby functions in Xenopus ciliary assembly, embryonic development, and the regulation of gene expression.Developmental biology · 2014Article
- Sip1 mediates an E-cadherin-to-N-cadherin switch during cranial neural crest EMT.The Journal of cell biology · 2013Article
- The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition.The Journal of cell biology · 2013Article
- Expression of TWIST1, Snail, Slug, and NF-κB and methylation of the TWIST1 promoter in mammary phyllodes tumor.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer.The American journal of pathology · 2012Review
- sizzled function and secreted factor network dynamics.Biology open · 2012Article
- Roles of ADAM13-regulated Wnt activity in early Xenopus eye development.Developmental biology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A NF-kappaB-Twist-Snail network controls axis and mesoderm formation in Drosophila. Using translation-blocking morpholinos and hormone-regulated proteins, we demonstrate the presence of an analogous network in the early Xenopus embryo. Loss of twist (twist1) function leads to a reduction of mesoderm and neural crest markers, an increase in apoptosis, and a decrease in snail1 (snail) and snail2 (slug) mRNA levels. Injection of snail2 mRNA rescues twist's loss of function phenotypes and visa versa. In the early embryo NF-kappaB/RelA regulates twist, snail2, and snail1 mRNA levels; similarly Nodal/Smad2 regulate twist, snail2, snail1, and relA RNA levels. Both Twist and Snail2 negatively regulate levels of cerberus RNA, which encodes a Nodal, bone morphogenic protein (BMP), and Wnt inhibitor. Cerberus's anti-Nodal activity inhibits NF-kappaB activity and decreases relA RNA levels. These results reveal both conserved and unexpected regulatory interactions at the core of a vertebrate's mesodermal specification network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.