ArticleDevelopmental biology2009
Functional equivalence of the zinc finger transcription factors Osr1 and Osr2 in mouse development.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- The making of cells and organs in xenogeneic animal bioreactor.Signal transduction and targeted therapy · 2026Review
- Integrated pan-cancer profiling highlights OSR2 as a prognostic indicator and immune-associated biomarker.Discover oncology · 2026Article
- Molecular Regulation of Palatogenesis and Clefting: An Integrative Analysis of Genetic, Epigenetic Networks, and Environmental Interactions.International journal of molecular sciences · 2025Review
- OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity.The Journal of clinical investigation · 2023Article
- Feeding during hibernation shifts gene expression toward active season levels in brown bears (Physiological genomics · 2023Article
- Gene Regulatory Networks and Signaling Pathways in Palatogenesis and Cleft Palate: A Comprehensive Review.Cells · 2023Review
- Deficiency ofInternational journal of molecular sciences · 2023Article
- Disrupted tenogenesis in masseter as a potential cause of micrognathia.International journal of oral science · 2022Article
- Spatiotemporal Gene Expression Regions along the Anterior-Posterior Axis in Mouse Embryos before and after Palatal Elevation.International journal of molecular sciences · 2022Article
- Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice.Communications biology · 2021Article
- Deficiency of calpain-6 inhibits primary ciliogenesis.BMB reports · 2019Article
- Comparative transcriptome and metabolome analysis suggests bottlenecks that limit seed and oil yields in transgenicBiotechnology for biofuels · 2018Article
- Identification of Osr2 Transcriptional Target Genes in Palate Development.Journal of dental research · 2017Article
- Functional Equivalence of the SOX2 and SOX3 Transcription Factors in the Developing Mouse Brain and Testes.Genetics · 2017Article
- A novel allele of Alx4 results in reduced Fgf10 expression and failure of eyelid fusion in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Evolution of transcription factor function as a mechanism for changing metazoan developmental gene regulatory networks.EvoDevo · 2015Review
- Altered FGF Signaling Pathways Impair Cell Proliferation and Elevation of Palate Shelves.PloS one · 2015Article
- A glance at methods for cleft palate repair.Iranian Red Crescent medical journal · 2014Review
- The OSR1 rs12329305 polymorphism contributes to the development of congenital malformations in cases of stillborn/neonatal death.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Odd-skipped related-1 controls neural crest chondrogenesis during tongue development.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Osr1 and Osr2 are the only mammalian homologs of the Drosophila odd-skipped family developmental regulators. The Osr1 protein contains three zinc-finger motifs whereas Osr2 exists in two isoforms, containing three and five zinc-finger motifs respectively, due to alternative splicing of the transcripts. Targeted null mutations in these genes in mice resulted in distinct phenotypes, with heart and urogenital developmental defects in Osr1(-/-) mice and with cleft palate and open eyelids at birth in Osr2(-/-) mice. To investigate whether these contrasting mutant phenotypes are due to differences in their protein structure or to differential expression patterns, we generated mice in which the endogenous Osr2 coding region was replaced by either Osr1 cDNA or Osr2A cDNA encoding the five-finger isoform. The knockin alleles recapitulated endogenous Osr2 mRNA expression patterns in most tissues and completely rescued cleft palate and cranial skeletal developmental defects of Osr2(-/-) mice. Mice hemizygous or homozygous for either knockin allele exhibited open-eyelids at birth, which correlated with differences in expression patterns between the knockin allele and the endogenous Osr2 gene during eyelid development. Molecular marker analyses in Osr2(-/-) and Osr2(Osr1ki/Osr1ki) mice revealed that Osr2 controls eyelid development through regulation of the Fgf10-Fgfr2 signaling pathway and that Osr1 rescued Osr2 function in maintaining Fgf10 expression during eyelid development in Osr2(Osr1ki/Osr1ki) mice. These results indicate that the distinct functions of Osr1 and Osr2 during mouse development result from evolutionary divergence of their cis regulatory sequences rather than distinct biochemical activities of their protein products.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.