ArticleDevelopmental biology2009
Chordin is required for neural but not axial development in sea urchin embryos.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 76 citations in OpenAlex.
- PFAS compounds PFOA and Gen X are teratogenic to sea urchin embryos.Developmental biology · 2025Article
- CMTM4 is an adhesion modulator that regulates skeletal patterning and primary mesenchyme cell migration in sea urchin embryos.Developmental biology · 2025Article
- Development of a larval nervous system in the sea urchin.Current topics in developmental biology · 2022Review
- Developmental single-cell transcriptomics in the Lytechinus variegatus sea urchin embryo.Development (Cambridge, England) · 2021Article
- Developmental origin of peripheral ciliary band neurons in the sea urchin embryo.Developmental biology · 2020Article
- Neurogenesis in the sea urchin embryo is initiated uniquely in three domains.Development (Cambridge, England) · 2018Article
- The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions.Journal of visualized experiments : JoVE · 2017Article
- Divergence of ectodermal and mesodermal gene regulatory network linkages in early development of sea urchins.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Developmental gene regulatory networks in sea urchins and what we can learn from them.F1000Research · 2016Review
- A deuterostome origin of the Spemann organiser suggested by Nodal and ADMPs functions in Echinoderms.Nature communications · 2015Article
- Ectopic hbox12 Expression Evoked by Histone Deacetylase Inhibition Disrupts Axial Specification of the Sea Urchin Embryo.PloS one · 2015Article
- Early asymmetric cues triggering the dorsal/ventral gene regulatory network of the sea urchin embryo.eLife · 2014Article
- Specification to biomineralization: following a single cell type as it constructs a skeleton.Integrative and comparative biology · 2014Article
- Oral-aboral axis specification in the sea urchin embryo, IV: hypoxia radializes embryos by preventing the initial spatialization of nodal activity.Developmental biology · 2014Article
- Short-range Wnt5 signaling initiates specification of sea urchin posterior ectoderm.Development (Cambridge, England) · 2013Article
- Gene regulatory network for neurogenesis in a sea star embryo connects broad neural specification and localized patterning.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Follistatin antagonizes activin signaling and acts with notum to direct planarian head regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Sequencing and analysis of the gastrula transcriptome of the brittle star Ophiocoma wendtii.EvoDevo · 2012Article
- Axial patterning interactions in the sea urchin embryo: suppression of nodal by Wnt1 signaling.Development (Cambridge, England) · 2012Article
- Pantropic retroviruses as a transduction tool for sea urchin embryos.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
The oral-aboral (OA) axis in the sea urchin is specified by the TGFbeta family members Nodal and BMP2/4. Nodal promotes oral specification, whereas BMP2/4, despite being expressed in the oral territory, is required for aboral specification. This study explores the role of Chordin (Chd) during sea urchin embryogenesis. Chd is a secreted BMP inhibitor that plays an important role in axial and neural specification and patterning in Drosophila and vertebrate embryos. In Lytechinus variegatus embryos, Chd and BMP2/4 are functionally antagonistic. Both are expressed in overlapping domains in the oral territory prior to and during gastrulation. Perturbation shows that, surprisingly, Chd is not involved in OA axis specification. Instead, Chd is required both for normal patterning of the ciliary band at the OA boundary and for development of synaptotagmin B-positive (synB) neurons in a manner that is reciprocal with BMP2/4. Chd expression and synB-positive neural development are both downstream from p38 MAPK and Nodal, but not Goosecoid. These data are summarized in a model for synB neural development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.