ArticleDevelopmental biology2009
Hedgehog does not guide migrating Drosophila germ cells.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Harnessing the Power ofCold Spring Harbor perspectives in biology · 2026Review
- Hedgehog and Drosophila germ cell migration.Development (Cambridge, England) · 2025Review
- The journey of a generation: advances and promises in the study of primordial germ cell migration.Development (Cambridge, England) · 2024Article
- Hedgehog signaling guides migration of primordial germ cells to the Drosophila somatic gonad.Genetics · 2023Article
- Coordination of canonical and noncanonical Hedgehog signalling pathways mediated by WDR11 during primordial germ cell development.Scientific reports · 2023Article
- Preformation and epigenesis converge to specify primordial germ cell fate in the early Drosophila embryo.PLoS genetics · 2022Article
- Hedgehog signaling and Tre1 regulate actin dynamics through PI(4,5)PCell reports · 2021Article
- Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration.Nature communications · 2020Article
- Hedgehog signaling establishes precursors for germline stem cell niches by regulating cell adhesion.The Journal of cell biology · 2017Article
- Finding their way: themes in germ cell migration.Current opinion in cell biology · 2016Review
- Role of the ABC transporter Mdr49 in Hedgehog signaling and germ cell migration.Development (Cambridge, England) · 2016Article
- The Hedgehog Signalling Pathway in Cell Migration and Guidance: What We Have Learned from Drosophila melanogaster.Cancers · 2015Review
- Article
- The hedgehog pathway gene shifted functions together with the hmgcr-dependent isoprenoid biosynthetic pathway to orchestrate germ cell migration.PLoS genetics · 2013Article
- Sex and hedgehog: roles of genes in the hedgehog signaling pathway in mammalian sexual differentiation.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Review
- Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent.Developmental biology · 2009Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
In many species, the germ cells, precursors of sperm and egg, migrate during embryogenesis. The signals that regulate this migration are thus essential for fertility. In flies, lipid signals have been shown to affect germ cell guidance. In particular, the synthesis of geranylgeranyl pyrophosphate through the 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (Hmgcr) pathway is critical for attracting germ cells to their target tissue. In a genetic analysis of signaling pathways known to affect cell migration of other migratory cells, we failed to find a role for the Hedgehog (Hh) pathway in germ cell migration. However, previous reports had implicated Hh as a germ cell attractant in flies and suggested that Hh signaling is enhanced through the action of the Hmgcr pathway. We therefore repeated several critical experiments and carried out further experiments to test specifically whether Hh is a germ cell attractant in flies. In contrast to previously reported findings and consistent with findings in zebrafish our data do not support the notion that Hh has a direct role in the guidance of migrating germ cells in flies.
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Registered trials
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