Trial reportVeterinary research
The food contaminant fumonisin B(1) reduces the maturation of porcine CD11R1(+) intestinal antigen presenting cells and antigen-specific immune responses, leading to a prolonged intestinal ETEC infection.
Trial report in Veterinary research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Modulation of intestinal functions following mycotoxin ingestion: meta-analysis of published experiments in animals.Toxins · 2013Pooled it
- Synbiotic supplementation modulates humoral immunity and cecal microbiota in broiler chickens exposed to subclinical doses of fumonisins and deoxynivalenol.Frontiers in physiology · 2026Article
- Comparative proteomic analysis indicates differential responses to fumonisin BMycotoxin research · 2025Article
- Fumonisin BToxins · 2025Article
- Exploring the modulatory role of bovine lactoferrin on the microbiome and the immune response in healthy and Shiga toxin-producing E. coli challenged weaned piglets.Journal of animal science and biotechnology · 2024Article
- Article
- Pseudorabies Virus Infection Triggers NF-κB Activation via the DNA Damage Response but Actively Inhibits NF-κB-Dependent Gene Expression.Journal of virology · 2021Article
- Antibody-Mediated Targeting of Antigens to Intestinal Aminopeptidase N Elicits Gut IgA Responses in Pigs.Frontiers in immunology · 2021Article
- The Evidence for a Causal Link Between Disease and Damaging Behavior in Pigs.Frontiers in veterinary science · 2021Review
- β-Glucan-Induced IL-10 Secretion by Monocytes Triggers Porcine NK Cell Cytotoxicity.Frontiers in immunology · 2021Article
- Advances in Oral Subunit Vaccine Design.Vaccines · 2020Review
- Mycotoxin and Gut Microbiota Interactions.Toxins · 2020Review
- Maternal Supplementation of Food Ingredient (Prebiotic) or Food Contaminant (Mycotoxin) Influences Mucosal Immune System in Piglets.Nutrients · 2020Article
- Pseudorabies Virus Infection of Epithelial Cells Leads to Persistent but Aberrant Activation of the NF-κB Pathway, Inhibiting Hallmark NF-κB-Induced Proinflammatory Gene Expression.Journal of virology · 2020Article
- Fumonisins at Doses below EU Regulatory Limits Induce Histological Alterations in Piglets.Toxins · 2019Article
- In Vitro Transcriptome Response to a Mixture ofInternational journal of molecular sciences · 2018Article
- Saccharomyces cerevisiae Boulardii Reduces the Deoxynivalenol-Induced Alteration of the Intestinal Transcriptome.Toxins · 2018Article
- Risks for animal health related to the presence of fumonisins, their modified forms and hidden forms in feed.EFSA journal. European Food Safety Authority · 2018Article
- Article
- Evaluation of cellular and molecular impact of zearalenone and Escherichia coli co-exposure on IPEC-1 cells using microarray technology.BMC genomics · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Consumption of food or feed contaminated with fumonisin B(1) (FB(1)), a mycotoxin produced by Fusarium verticillioides, can lead to disease in humans and animals. The present study was conducted to examine the effect of FB1 intake on the intestinal immune system. Piglets were used as a target and as a model species for humans since their gastro-intestinal tract is very similar. The animals were orally exposed to a low dose of FB(1) (1 mg/kg body weight FB(1)) for 10 days which did not result in clinical signs. However, when compared to non-exposed animals, FB(1)-exposed animals showed a longer shedding of F4(+) enterotoxigenic Escherichia coli (ETEC) following infection and a lower induction of the antigen-specific immune response following oral immunization. Further analyses to elucidate the mechanisms behind these observations revealed a reduced intestinal expression of IL-12p40, an impaired function of intestinal antigen presenting cells (APC), with decreased upregulation of Major Histocompatibility Complex Class II molecule (MHC-II) and reduced T cell stimulatory capacity upon stimulation. Taken together, these results indicate an FB(1)-mediated reduction of in vivo APC maturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.