ArticleBritish journal of haematology2009
Inhibitor of DASH proteases affects expression of adhesion molecules in osteoclasts and reduces myeloma growth and bone disease.
Article in British journal of haematology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- The Role and Application of Fibroblast Activating Protein.Current molecular medicine · 2024Review
- Anti-cancer effect of targeting fibroblast activation protein alpha in glioblastoma through remodeling macrophage phenotype and suppressing tumor progression.CNS neuroscience & therapeutics · 2023Article
- The role of fibroblast activation protein in health and malignancy.Cancer metastasis reviews · 2020Review
- Targeting of activated fibroblasts for imaging and therapy.EJNMMI radiopharmacy and chemistry · 2019Review
- CD26 is a potential therapeutic target by humanized monoclonal antibody for the treatment of multiple myeloma.Blood cancer journal · 2018Article
- Fibroblast activation protein α in tumor microenvironment: recent progression and implications (review).Molecular medicine reports · 2015Review
- Article
- Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions.Clinical & experimental metastasis · 2011Article
- Targeting myeloma-osteoclast interaction with Vγ9Vδ2 T cells.International journal of hematology · 2011Article
- Bone metastasis: mechanisms and therapeutic opportunities.Nature reviews. Endocrinology · 2011Review
- Advances in the understanding of myeloma bone disease and tumour growth.British journal of haematology · 2010Review
- Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Dipeptidyl peptidase (DPP) IV activity and/or structure homologues (DASH) are serine proteases implicated in tumourigenesis. We previously found that a DASH protease, fibroblast activation protein (FAP), was involved in osteoclast-induced myeloma growth. Here we further demonstrated expression of various adhesion molecules in osteoclasts cultured alone or cocultured with myeloma cells, and tested the effects of DASH inhibitor, PT-100, on myeloma cell growth, bone disease, osteoclast differentiation and activity, and expression of adhesion molecules in osteoclasts. PT-100 had no direct effects on viability of myeloma cells or mature osteoclasts, but significantly reduced survival of myeloma cells cocultured with osteoclasts. Real-time PCR array for 85 adhesion molecules revealed upregulation of 17 genes in osteoclasts after coculture with myeloma cells. Treatment of myeloma/osteoclast cocultures with PT-100 significantly downregulated 18 of 85 tested genes in osteoclasts, some of which are known to play roles in tumourigenesis and osteoclastogenesis. PT-100 also inhibited osteoclast differentiation and subsequent pit formation. Resorption activity of mature osteoclasts and differentiation of osteoblasts were not affected by PT-100. In primary myelomatous severe combined immunodeficient (SCID)-hu mice PT-100 reduced osteoclast activity, bone resorption and tumour burden. These data demonstrated that DASH proteases are involved in myeloma bone disease and tumour growth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.