Evidence map›Paper›PMID 19388174›Full record

ReviewVaccine2008

The iC3b receptor of Candida albicans and its roles in pathogenesis.

Margaret K Hostetter

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Vaccine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Sticking to the Subject: Multifunctionality in Microbial Adhesins.Journal of fungi (Basel, Switzerland) · 2023
    Review
  3. Article
  4. Mechanisms of PathogenicFrontiers in cellular and infection microbiology · 2020
    Review
  5. Effect of heparin and other factors associated with complications of peripherally inserted central venous catheters in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Margaret K HostetterDepartment of Pediatrics, Yale School of Medicine, 333 Cedar Street, LMP 4085, P.O. Box 208064, New Haven, CT 06520-8064, USA. margaret.hostetter@yale.edu
Yale University · US

Funding

Biology of Int1p in Canadida albicans FungemiaR01AI050813 · NIAID · YALE UNIVERSITY · PI HOSTETTER, MARGARET K · 2002 to 2006
$1.7M
NIAID NIH HHS R01 AI050813
6 · The paper itself

Abstract

On the basis of biochemical and immunologic studies, a receptor for iC3b with some activities reminiscent of the integrins CD11b and CD11c was defined on the cell wall of clinical and laboratory isolates of Candida albicans. The INT1 gene encodes a protein of 1659 amino acids; the Int1 protein participates in adhesion to epithelial cells in vitro and in vivo. Int1 is essential for hyphal morphogenesis and virulence in a murine model. Recent evidence points to the amino terminus of Int1 as the source of a peptide, Pep263, with superantigen-like activities.

Indexed as

AdhesivenessCandida albicansCell Adhesion MoleculesCloning, MolecularFungal ProteinsHeparinReceptors, Complement 3bVirulencealphaINT1 protein, Candida albicansCell Adhesion MoleculesFungal ProteinsHeparinReceptors, Complement 3b

Identifiers

PMID19388174
PMCPMC2768074
OpenAlexW2069696875

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.