ReviewVaccine2008
Complement and its role in protection and pathogenesis of flavivirus infections.
Review in Vaccine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Role of CD61+ cells in thrombocytopenia of dengue patients.International journal of hematology · 2012Trial
- Antibody-Dependent Enhancement in Flavivirus Infections: From Fc Receptor Signaling to Vaccine and Therapeutic Design.Viruses · 2026Review
- Encephalitis: Predictive Role of Clinical and Diagnostic Data on Outcome-A Monocentric Study.Life (Basel, Switzerland) · 2025Article
- Long-term Elevation of Complement Factors in Cerebrospinal Fluid of Patients With Borna Disease Virus 1 Encephalitis.The Journal of infectious diseases · 2024Article
- Machine learning-based gene expression biomarkers to distinguish Zika and Dengue virus infections: implications for diagnosis.Virusdisease · 2024Article
- Article
- Review
- Dengue virus infection - a review of pathogenesis, vaccines, diagnosis and therapy.Virus research · 2023Review
- Low serum complement level is associated with higher mortality in tuberculous meningitis: a retrospective cohort study.Encephalitis (Seoul, Korea) · 2023Article
- Antibody Fc characteristics and effector functions correlate with protection from symptomatic dengue virus type 3 infection.Science translational medicine · 2022Article
- Article
- Dengue and the Lectin Pathway of the Complement System.Viruses · 2021Review
- Incorporation of CD55 into the Zika Viral Envelope Contributes to Its Stability against Human Complement.Viruses · 2021Article
- Functional Profiling of Antibody Immune Repertoires in Convalescent Zika Virus Disease Patients.Frontiers in immunology · 2021Article
- Role of IFN and Complements System: Innate Immunity in SARS-CoV-2.Journal of inflammation research · 2020Review
- Interference of the Zika Virus E-Protein With the Membrane Attack Complex of the Complement System.Frontiers in immunology · 2020Article
- Zika virus and the nonmicrocephalic fetus: why we should still worry.American journal of obstetrics and gynecology · 2019Review
- Transcytosis Involvement in Transport System and Endothelial Permeability of Vascular Leakage during Dengue Virus Infection.Viruses · 2018Review
- Active Human Complement Reduces the Zika Virus Load via Formation of the Membrane-Attack Complex.Frontiers in immunology · 2018Article
- Complement alternative pathway genetic variation and Dengue infection in the Thai population.Clinical and experimental immunology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The complement system is a family of serum and cell surface proteins that recognize pathogen-associated molecular patterns, altered-self ligands, and immune complexes. Activation of the complement cascade triggers several antiviral functions including pathogen opsonization and/or lysis, and priming of adaptive immune responses. In this review, we will examine the role of complement activation in protection and/or pathogenesis against infection by Flaviviruses, with an emphasis on experiments with West Nile and Dengue viruses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.