ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2009
BDNF, relative preference, and reward circuitry responses to emotional communication.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 74 citations in OpenAlex.
- Effects of the BDNF Val66Met polymorphism and met allele load on declarative memory related neural networks.PloS one · 2013Trial
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- Discrete, recurrent, and scalable patterns in non-operant judgement underlie affective picture ratings.Cognitive processing · 2025Article
- A novel approach to anxiety level prediction using small sets of judgment and survey variables.Npj mental health research · 2024Article
- Predicting COVID-19 Vaccination Uptake Using a Small and Interpretable Set of Judgment and Demographic Variables: Cross-Sectional Cognitive Science Study.JMIR public health and surveillance · 2024Article
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- The Prevalence of Psychotic Symptoms, Violent Ideation, and Disruptive Behavior in a Population With SARS-CoV-2 Infection: Preliminary Study.JMIR formative research · 2022Article
- Preliminary Report: Localized Cerebral Blood Flow Mediates the Relationship between Progesterone and Perceived Stress Symptoms among Female Collegiate Club Athletes after Mild Traumatic Brain Injury.Journal of neurotrauma · 2021Article
- Examining the value of body gestures in social reward contexts.NeuroImage · 2020Article
- Sex differences in fear extinction.Neuroscience and biobehavioral reviews · 2019Review
- Interactive effect of 5-HTTLPR and BDNF polymorphisms on amygdala intrinsic functional connectivity and anxiety.Psychiatry research. Neuroimaging · 2019Article
- Dysmorphic contribution of neurotransmitter and neuroendocrine system polymorphisms to subtherapeutic mood states.Brain and behavior · 2019Article
- Anterior insula activation during inhibition to smoking cues is associated with ability to maintain tobacco abstinence.Addictive behaviors reports · 2018Article
- Increased insula-putamen connectivity in X-linked dystonia-parkinsonism.NeuroImage. Clinical · 2018Article
- Keypress-Based Musical Preference Is Both Individual and Lawful.Frontiers in neuroscience · 2017Article
- A Quantitative Relationship between Signal Detection in Attention and Approach/Avoidance Behavior.Frontiers in psychology · 2017Article
- Neural mechanisms of sensitivity to peer information in young adult cannabis users.Cognitive, affective & behavioral neuroscience · 2016Article
- Higher reward value of starvation imagery in anorexia nervosa and association with the Val66Met BDNF polymorphism.Translational psychiatry · 2016Article
- Variable activation in striatal subregions across components of a social influence task in young adult cannabis users.Brain and behavior · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
Brain derived neurotrophic factor (BDNF) regulates neural development and synaptic transmission. We have tested the hypothesis that functional variation in the BDNF gene (Val66Met polymorphism, rs6265) affects brain reward circuitry encoding human judgment and decision-making regarding relative preference. We quantified relative preference among faces with emotional expressions (angry, fearful, sad, neutral, and happy) by a keypress procedure performed offline to measure effort traded for viewing time. Keypress-based relative preferences across the ensemble of faces were mirrored significantly by fMRI signal in the orbitofrontal cortex, amygdala, and hippocampus when passively viewing these faces. For these three brain regions, there was also a statistically significant group difference by BDNF genotype in the fMRI responses to the emotional expressions. In comparison with Val/Met heterozygotes, Val/Val individuals preferentially sought exposure to positive emotions (e.g., happy faces) and had stronger regional fMRI activation to aversive stimuli (e.g., angry, fearful, and sad faces). BDNF genotype accounted for approximately 30% of the variance in fMRI signal that mirrors keypress responses to these stimuli. This study demonstrates that functional allelic variation in BDNF modulates human brain circuits processing reward/aversion information and relative preference transactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.