ArticleChembiochem : a European journal of chemical biology2009
GilR, an unusual lactone-forming enzyme involved in gilvocarcin biosynthesis.
Article in Chembiochem : a European journal of chemical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Biosynthetic Strategies of Berberine Bridge Enzyme-like Flavoprotein Oxidases toward Structural Diversification in Natural Product Biosynthesis.Biochemistry · 2024Review
- Engineering BioBricks for Deoxysugar Biosynthesis and Generation of New Tetracenomycins.ACS omega · 2023Article
- The functional differentiation of the post-PKS tailoring oxygenases contributed to the chemical diversities of atypical angucyclines.Synthetic and systems biotechnology · 2018Review
- Flavoenzyme CrmK-mediated substrate recycling in caerulomycin biosynthesis.Chemical science · 2016Article
- Baeyer-Villiger C-C bond cleavage reaction in gilvocarcin and jadomycin biosynthesis.Journal of the American Chemical Society · 2012Article
- Catalytic and structural role of a conserved active site histidine in berberine bridge enzyme.Biochemistry · 2012Article
- Complexity generation during natural product biosynthesis using redox enzymes.Current opinion in chemical biology · 2012Review
- Roles of the synergistic reductive O-methyltransferase GilM and of O-methyltransferase GilMT in the gilvocarcin biosynthetic pathway.Journal of the American Chemical Society · 2012Article
- Draft genome of Omphalotus olearius provides a predictive framework for sesquiterpenoid natural product biosynthesis in Basidiomycota.Chemistry & biology · 2012Article
- Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology.Current opinion in chemical biology · 2012Review
- Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis.Natural product reports · 2012Review
- Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis.Angewandte Chemie (International ed. in English) · 2012Article
- The crystal structure and mechanism of an unusual oxidoreductase, GilR, involved in gilvocarcin V biosynthesis.The Journal of biological chemistry · 2011Article
- Engineered biosynthesis of gilvocarcin analogues with altered deoxyhexopyranose moieties.Applied and environmental microbiology · 2011Article
- Cloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clusters.Chembiochem : a European journal of chemical biology · 2010Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Last at last: The terminal step of the gilvocarcin V (GV) biosynthetic pathway is an unusual lactone formation. Here we show that the enzyme, GilR, dehydrogenates the hemiacetal moiety of pregilvocarcin V to the lactone found in GV by using covalently bound FAD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.