ArticleJournal of assisted reproduction and genetics2009
Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome.
Article in Journal of assisted reproduction and genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 9 of them syntheses that pooled it.
What it found
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Who cites it
54 citing papers in PubMed, 9 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- The Role of Aromatic Amino Acids in Polycystic Ovary Syndrome through Patients' Blood Metabolic Profiling: A Systematic Review of the Past Five Years.Journal of proteome research · 2025Pooled it
- Polymorphisms in FSHR modulating susceptibility to polycystic ovary syndrome: an updated meta-analysis.Journal of ovarian research · 2023Pooled it
- CYP17A1 (rs74357) polymorphism and polycystic ovary syndrome risk: a systemic review and meta-analysis.Acta bio-medica : Atenei Parmensis · 2023Pooled it
- Association of FSHR and DENND1A polymorphisms with polycystic ovary syndrome: a meta-analysis.JBRA assisted reproduction · 2023Pooled it
- Association ofFrontiers in genetics · 2023Pooled it
- The Association of CYP17A1, CYP19A1, and SHBG Gene Polymorphisms in Polycystic Ovary Syndrome Susceptibility: A Systematic Review and Meta-Analysis.Frontiers in physiology · 2022Pooled it
- CYP1A1 and GSTP1 gene variations in breast cancer: a systematic review and case-control study.Familial cancer · 2016Pooled it
- The association between polymorphism of INSR and polycystic ovary syndrome: a meta-analysis.International journal of molecular sciences · 2015Pooled it
- Genetic variants associated with insulin signaling and glucose homeostasis in the pathogenesis of insulin resistance in polycystic ovary syndrome: a systematic review.Journal of assisted reproduction and genetics · 2013 · on this mapPooled it
- Function of anti-müllerian hormone (AMH), gonadotropins and FSHR rs6166 genetic variant in the pathogenesis and diagnostic assessment of polycystic ovary syndrome.Journal of education and health promotion · 2026Article
- Genomic and Transcriptomic Variations ofJournal of nutrition and metabolism · 2026Article
- Meta-analysis ofJournal of diabetes and metabolic disorders · 2025Review
- Pathogenic variation in insulin resistance genes is common in polycystic ovary syndrome (PCOS): a strategy for causal gene discovery using whole-exome sequencing (WES) in complex traits.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Roles of estrogen and its receptors in polycystic ovary syndrome.Frontiers in cell and developmental biology · 2024Review
- Analyzing the Impact of FSHR Variants on Polycystic Ovary Syndrome-a Case-Control Study in Punjab.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Article
- Molecular role of non-exonic variants inFrontiers in endocrinology · 2023Article
- Deconstructing a Syndrome: Genomic Insights Into PCOS Causal Mechanisms and Classification.Endocrine reviews · 2022Article
- A Review onGenes · 2022Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolycystic ovary syndrome (PCOS), whose genetic basis is not completely well understood, is the most common endocrine disorder in women and it typically develops during adolescence. The aim of this study is to investigate the possible association between single nucleotide polymorphisms (SNPs) of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes and PCOS in adolescent girls.
methodsDNA samples from forty-four adolescent girls with PCOS and 50 healthy controls were analyzed by PCR-RFLP and direct DNA sequencing to determine the genotypic frequency of 17 different polymorphic loci on the FSHR (A307T, N680S), CYP17 (-34 T/C), CYP1A1 (T6235C), CAPN10 (44, 43, 19, 63), INSR (exon 17 C/T), SERPINE1 (4G/5G) genes. Genotyping of exon 12 (six polymorphisms) and intron 12 (one polymorphism) of INSR gene by direct DNA sequencing was performed for the first time in this study.
resultsNo significant differences were observed in the genotype and allele distributions of above mentioned polymorphisms between cases and control groups.
conclusionOur data does not support an association between SNPs of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes and susceptibility to PCOS or related traits in Turkish adolescent girls.
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