ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2009
Survival following treatment for intracranial ependymoma: a review.
Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Cerebello-Pontine Angle Tumors in Children: An Update on Challenging Neoplasms.Diagnostics (Basel, Switzerland) · 2026Article
- Algorithm-based assessment of T-cell dysfunction and exclusion to forecast ICB sensitivity in pediatric brain ependymoma.Journal of neuro-oncology · 2025Article
- Outcomes following management of relapsed pediatric posterior fossa ependymoma in the molecular era.Journal of neuro-oncology · 2023Article
- Supratentorial pediatric cortical ependymomas: a comprehensive retrospective study.Neurosurgical review · 2021Review
- Ependymoma Pediatric Brain Tumor Protein Fingerprinting by Integrated Mass Spectrometry Platforms: A Pilot Investigation.Cancers · 2020Article
- Craniospinal irradiation as part of re-irradiation for children with recurrent intracranial ependymoma.Neuro-oncology · 2019Article
- Significance of cyclin D1 overexpression in progression and radio-resistance of pediatric ependymomas.Oncotarget · 2018Article
- Ependymomas: Prognostic Factors and Outcome Analysis in a Retrospective Series of 33 Patients.Brain tumor research and treatment · 2017Article
- Quantitative imaging analysis of posterior fossa ependymoma location in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
- Overcoming Chemoresistance of Pediatric Ependymoma by Inhibition of STAT3 Signaling.Translational oncology · 2015Article
- Nanoparticle mediated silencing of DNA repair sensitizes pediatric brain tumor cells to γ-irradiation.Molecular oncology · 2015Article
- Chromosomal anomalies and prognostic markers for intracranial and spinal ependymomas.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2012Review
- Cerebellopontine angle ependymoma in a 2-year- old child.Journal of neurosciences in rural practice · 2012Article
- Pediatric infratentorial ependymoma: prognostic significance of anaplastic histology.Journal of neuro-oncology · 2012Article
- Predictors of survival among pediatric and adult ependymoma cases: a study using Surveillance, Epidemiology, and End Results data from 1973 to 2007.Neuroepidemiology · 2012Article
- Apurinic/apyrimidinic endonuclease is inversely associated with response to radiotherapy in pediatric ependymoma.International journal of cancer · 2011Article
- Challenging issues in pediatric oncology.Nature reviews. Clinical oncology · 2011Review
- Pediatric anaplastic parenchymal ependymoma: case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2011Article
- Gonadotropin-dependent precocious puberty: neoplastic causes and endocrine considerations.International journal of pediatric endocrinology · 2011Article
- Posterior fossa ependymomas: new radiological classification with surgical correlation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The actual definition of survival rates following treatment for intracranial ependymomas is substantially influenced by the strict interaction among different factors. Age, location, and grading, for example, act together, negatively influencing the prognosis of younger children also invariably influenced by the more demanding role of surgery and the still limited use, up to recently, of radiotherapy under 3 years of age. In the same direction, the worse prognosis in most series of infratentorial ependymomas if compared with their supratentorial counterpart should be cautiously considered, midline posterior fossa tumors having completely different implications from those originating or predominantly extending to the cerebellopontine angle, where the extent of surgery has more invariably to compare with patients' quality of life. New radiotherapic regimens and their applications in infancy are promisingly demonstrating an improvement of present prognostic criteria, with the limit of still insufficient information on their long-term secondary effects. Similarly, molecular biology research studies, though still in their preclinical stage, are prompting to change the concept of a substantially chemoresistant tumor helping to stratify these lesions with the final aim of targeted pharmacological therapies. In the present review paper, we investigated singularly the role that the more commonly considered prognostic factors have had in the literature on survival of children affected by intracranial ependymomas, trying to elucidate their cumulative effect on the actual knowledge of this issue.
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