ArticlePsychopharmacology2009
Anxiolytic-like effects induced by blockade of transient receptor potential vanilloid type 1 (TRPV1) channels in the medial prefrontal cortex of rats.
Article in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- The role of acid-sensitive ion channels in panic disorder: a systematic review of animal studies and meta-analysis of human studies.Translational psychiatry · 2018Pooled it
- Peptide Modulator of TRPV1 Channel Increases Long-Term Potentiation in the Hippocampus and Reduces Anxiety and Fear in Mice Under Acute Stress.Marine drugs · 2026Article
- Brain TRPV1 channel-mediated calcium influx: the immunomodulatory pathway of acupuncture in neuroinflammation.Frontiers in immunology · 2025Review
- The Study of TRPV1 Channels of the Central Nervous System and Their Effect on Anxiety in ICR Mice.Doklady. Biochemistry and biophysics · 2024Article
- Interrelated involvement of the endocannabinoid/endovanilloid (TRPV1) systems and epigenetic processes in anxiety- and working memory impairment-related behavioural effects of nicotine as a stressor.Addiction biology · 2024Article
- Anxiolytic Effect of Peptides from Sea Anemone Heteractis crispa, Modulators of TRPV1 and ASIC Channels.Doklady. Biochemistry and biophysics · 2022Article
- Transient Receptor Potential Vanilloid 1 Function at Central Synapses in Health and Disease.Frontiers in cellular neuroscience · 2022Review
- Blockade of the endovanilloid receptor, TRPV1, and of the endocannabinoid enzyme, FAAH, within the nucleus accumbens shell elicits anxiolytic-like effects in male rats.Neuroscience letters · 2020Article
- Effects of TRPV1 Activation by Capsaicin and Endogenous N-Arachidonoyl Taurine on Synaptic Transmission in the Prefrontal Cortex.Frontiers in neuroscience · 2020Article
- Auricular Electrical Stimulation Alleviates Headache through CGRP/COX-2/TRPV1/TRPA1 Signaling Pathways in a Nitroglycerin-Induced Migraine Rat Model.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Blockade of TRPV1 Inhibits Methamphetamine-induced Rewarding Effects.Scientific reports · 2018Article
- Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors.Experimental neurology · 2017Article
- AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets.PloS one · 2016Article
- Article
- The endocannabinoid system in guarding against fear, anxiety and stress.Nature reviews. Neuroscience · 2015Review
- Medial prefrontal cortex TRPV1 channels modulate the baroreflex cardiac activity in rats.British journal of pharmacology · 2015Article
- Reduced cholesterol is associated with the depressive-like behavior in rats through modulation of the brain 5-HT1A receptor.Lipids in health and disease · 2015Article
- Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Transient receptor potential vanilloid type 1 channel may modulate opioid reward.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- The blockade of transient receptor potential ankirin 1 (TRPA1) signalling mediates antidepressant- and anxiolytic-like actions in mice.British journal of pharmacology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe endocannabinoid anandamide, in addition to activating cannabinoid type 1 receptors (CB1), may act as an agonist at transient receptor potential vanilloid type 1 (TRPV1) channels. In the periaqueductal gray, CB1 activation inhibits, whereas TRPV1 increases, anxiety-like behavior. In the medial prefrontal cortex (mPFC), another brain region related to defensive responses, CB1 activation induces anxiolytic-like effects. However, a possible involvement of TRPV1 is still unclear.
objectivesIn the present study, we tested the hypothesis that TRPV1 channel contributes to the modulation of anxiety-like behavior in the mPFC. MATERIALS AND
methodsMale Wistar rats (n = 5-7 per group) received microinjections of the TRPV1 antagonist capsazepine (1-60 nmol) in the ventral portion of the mPFC and were exposed to the elevated plus maze (EPM) or to the Vogel conflict test.
resultsCapsazepine increased exploration of open arms in the EPM as well as the number of punished licks in the Vogel conflict test, suggesting anxiolytic-like effects. No changes in the number of entries into the enclosed arms were observed in the EPM, indicating that there were no changes in motor activity. Moreover, capsazepine did not interfere with water consumption or nociceptive threshold, discarding potential confounding factors for the Vogel conflict test.
conclusionsThese data suggest that TRPV1 in the ventral mPFC tonically inhibits anxiety-like behavior. TRPV1 could facilitate defensive responses opposing, therefore, the anxiolytic-like effects reported after local activation of CB1 receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.