ArticleThe EMBO journal2009
Lte1, Cdc14 and MEN-controlled Cdk inactivation in yeast coordinate rDNA decompaction with late telophase progression.
Article in The EMBO journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Repression of essential cell cycle genes increases cellular fitness.PLoS genetics · 2022Article
- The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control.International journal of molecular sciences · 2020Review
- Review
- The ribosomal DNA metaphase loop of Saccharomyces cerevisiae gets condensed upon heat stress in a Cdc14-independent TORC1-dependent manner.Cell cycle (Georgetown, Tex.) · 2018Article
- Article
- Cdc14 phosphatase: warning, no delay allowed for chromosome segregation!Current genetics · 2016Review
- The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis.Frontiers in cell and developmental biology · 2015Review
- Global analysis of cdc14 dephosphorylation sites reveals essential regulatory role in mitosis and cytokinesis.Molecular & cellular proteomics : MCP · 2014Article
- Condensin: crafting the chromosome landscape.Chromosoma · 2013Review
- The Lrs4-Csm1 monopolin complex associates with kinetochores during anaphase and is required for accurate chromosome segregation.Cell cycle (Georgetown, Tex.) · 2010Article
- Mitotic expression of Spo13 alters M-phase progression and nucleolar localization of Cdc14 in budding yeast.Genetics · 2010Article
- An overview of Cdk1-controlled targets and processes.Cell division · 2010Article
- Condensins promote coorientation of sister chromatids during meiosis I in budding yeast.Genetics · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism of chromatin compaction in mitosis has been well studied, while little is known about what controls chromatin decompaction in early G1 phase. We have localized the Condensin subunit Brn1 to a compact spiral of rDNA in mitotic budding yeast cells. Brn1 release and the resulting rDNA decompaction in late telophase coincided with mitotic spindle dissociation, and occurred asymmetrically (daughter cells first). We immunoprecipitated the GTP-exchange factor Lte1, which helps activate the mitotic exit network (MEN) in anaphase, with mitotic Brn1. In lteDelta cells Brn1 release was delayed, even at temperatures that do not impair mitotic exit. Mutations in MEN pathway components that act downstream of Lte1 similarly delayed rDNA decompaction. We found that Brn1 release in wild-type cells coincided with the release of Cdc14 phosphatase from the nucleolus and with mitotic CDK inactivation, yet it could be selectively delayed by perturbation of the MEN pathway. This may argue that different levels of Cdk inactivation control spindle disassembly and chromatin decompaction. Mutation of lte1 also impaired rotation of the nucleus in early G1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.