ReviewProceedings of the American Thoracic Society2009
Disrupting actin-myosin-actin connectivity in airway smooth muscle as a treatment for asthma?
Review in Proceedings of the American Thoracic Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- A life off the beaten track in biomechanics: Imperfect elasticity, cytoskeletal glassiness, and epithelial unjamming.Biophysics reviews · 2023Review
- Continuous Positive Airway Pressure (CPAP) in Non-Apneic Asthma: A Clinical Review of Current Evidence.Turkish thoracic journal · 2020Review
- Tissue traction microscopy to quantify muscle contraction within precision-cut lung slices.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins.Frontiers in pharmacology · 2020Article
- The RhoGAP SPV-1 regulates calcium signaling to control the contractility of the Caenorhabditis elegans spermatheca during embryo transits.Molecular biology of the cell · 2019Article
- The Strain on Airway Smooth Muscle During a Deep Inspiration to Total Lung Capacity.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- Spectrin regulates cell contractility through production and maintenance of actin bundles in the Caenorhabditis elegans spermatheca.Molecular biology of the cell · 2018Article
- Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy.American journal of respiratory cell and molecular biology · 2017Article
- Myosin activity drives actomyosin bundle formation and organization in contractile cells of theMolecular biology of the cell · 2017Article
- Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction.Scientific reports · 2016Article
- Forcing cells into shape: the mechanics of actomyosin contractility.Nature reviews. Molecular cell biology · 2015Review
- Emergence of airway smooth muscle mechanical behavior through dynamic reorganization of contractile units and force transmission pathways.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- A computational model of the response of adherent cells to stretch and changes in substrate stiffness.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Rho-kinase mediated cytoskeletal stiffness in skinned smooth muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Emerging targets for novel therapy of asthma.Current opinion in pharmacology · 2013Review
- Dilatation of the constricted human airway by tidal expansion of lung parenchyma.American journal of respiratory and critical care medicine · 2012Article
- Mechanics and function of the pulmonary vasculature: implications for pulmonary vascular disease and right ventricular function.Comprehensive physiology · 2012Review
- Emergence of airway smooth muscle functions related to structural malleability.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Review
- Airway response to acute mechanical stress in a human bronchial model of stretch.Critical care (London, England) · 2011Article
- The psychophysiology of blood-injection-injury phobia: looking beyond the diphasic response paradigm.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Breathing is known to functionally antagonize bronchoconstriction caused by airway muscle contraction. During breathing, tidal lung inflation generates force fluctuations that are transmitted to the contracted airway muscle. In vitro, experimental application of force fluctuations to contracted airway smooth muscle strips causes them to relengthen. Such force fluctuation-induced relengthening (FFIR) likely represents the mechanism by which breathing antagonizes bronchoconstriction. Thus, understanding the mechanisms that regulate FFIR of contracted airway muscle could suggest novel therapeutic interventions to increase FFIR, and so to enhance the beneficial effects of breathing in suppressing bronchoconstriction. Here we propose that the connectivity between actin filaments in contracting airway myocytes is a key determinant of FFIR, and suggest that disrupting actin-myosin-actin connectivity by interfering with actin polymerization or with myosin polymerization merits further evaluation as a potential novel approach for preventing prolonged bronchoconstriction in asthma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.