ReviewProceedings of the American Thoracic Society2009
The origins of asthma and chronic obstructive pulmonary disease in early life.
Review in Proceedings of the American Thoracic Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
104 citing papers in PubMed, 2 syntheses or guidelines pooled it, 237 citations in OpenAlex.
- Pooled it
- Pooled it
- Oral Vitamin C (500 mg/d) to Pregnant Smokers Improves Infant Airway Function at 3 Months (VCSIP). A Randomized Trial.American journal of respiratory and critical care medicine · 2019Trial
- Trial
- Early dysanapsis in experimental bronchopulmonary dysplasia: implications for lifelong lung disease.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- The elderly as a population at risk of chronic obstructive pulmonary disease mortality due to ambient ozone exposure: results from the Global Burden of Disease Study 2021.Environmental health : a global access science source · 2025Article
- Asthma Phenotypes and Biomarkers.Respiratory care · 2025Review
- Associations between prenatal metal and metalloid mixtures in teeth and reductions in childhood lung function.The Science of the total environment · 2024Article
- Associations of prenatal exposure to phthalates and their mixture with lung function in Mexican children.Journal of hazardous materials · 2024Article
- The Precision Medicine Era of Bronchiectasis.American journal of respiratory and critical care medicine · 2024Article
- Antenatal Endotoxin Induces Dysanapsis in Experimental Bronchopulmonary Dysplasia.American journal of respiratory cell and molecular biology · 2024Article
- Emerging role of cellular senescence in normal lung development and perinatal lung injury.Chinese medical journal pulmonary and critical care medicine · 2024Article
- Early-life pulmonary viral infection leads to long-term functional and lower airway structural changes in the lungs.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Exploring the link between the pediatric exposome, respiratory health, and executive function in children: a narrative review.Frontiers in public health · 2024Review
- Dysanapsis as a Determinant of Lung Function in Development and Disease.American journal of respiratory and critical care medicine · 2023Article
- Perception of Illness and Fear of Inhaled Corticosteroid Use among Parents of Children with Asthma.Children (Basel, Switzerland) · 2023Article
- Lung volumes differentiate the predominance of emphysemaERJ open research · 2023Article
- Early-life and health behaviour influences on lung function in early adulthood.The European respiratory journal · 2023Article
- Associations between early-life exposure to PMEnvironmental epidemiology (Philadelphia, Pa.) · 2023Article
- Innate Immunity, Epithelial Plasticity, and Remodeling in Asthma.Advances in experimental medicine and biology · 2023Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Results from birth cohort and cross-sectional studies of young children with wheezing have uncovered strong associations between both lung function and immune responses in early life and the subsequent development of persistent wheezing and chronic airway obstruction up to mid-adulthood. It is now apparent that the pattern of bronchial hyperresponsiveness, deficits in lung function, and structural airway remodeling that are characteristic of asthma may be already established during the preschool years in most patients. Interactions between acute viral infections, especially those due to rhinovirus and respiratory syncytial virus, and exposure to perennial aeroallergens may induce persistent alterations in immune responses and airway function in susceptible subjects. Similarly, deficits in airway function present shortly after birth predict airflow limitation in early adult life, which in turn is a strong predisposing factor for chronic obstructive pulmonary disease. The fact that these alterations are more likely to occur during early life and even in utero than later during childhood suggests that there a developmental window of susceptibility during which exposures can disrupt normal growth trajectories. Novel strategies for primary prevention of chronic respiratory diseases will be based on the identification of the genetic and environmental factors that interactively cause these disruptions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.