ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Staircase currents in motoneurons: insight into the spatial arrangement of calcium channels in the dendritic tree.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Ionic Mechanisms Underlying Bistability in Spinal Motoneurons: Insights from a Computational Model.bioRxiv : the preprint server for biology · 2025Article
- Multiple patterns of persistent inward currents with multiple types of repetitive firings in medullary serotonergic neurons of mice: An experimental and modeling study.PLoS computational biology · 2025Article
- Ionic mechanisms underlying bistability in spinal motoneurons: insights from a computational model.Frontiers in cellular neuroscience · 2025Article
- Bifurcation analysis of motoneuronal excitability mechanisms under normal and ALS conditions.Frontiers in cellular neuroscience · 2023Article
- Article
- Location, location, location: the organization and roles of potassium channels in mammalian motoneurons.The Journal of physiology · 2021Article
- Calpain fosters the hyperexcitability of motoneurons after spinal cord injury and leads to spasticity.eLife · 2019Article
- Persistent Sodium Current Drives Excitability of Immature Renshaw Cells in Early Embryonic Spinal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Voltage-gated calcium channels are abnormal in cultured spinal motoneurons in the G93A-SOD1 transgenic mouse model of ALS.Neurobiology of disease · 2016Article
- Contribution of intrinsic motoneuron properties to discharge hysteresis and its estimation based on paired motor unit recordings: a simulation study.Journal of neurophysiology · 2015Article
- Comparison of dendritic calcium transients in juvenile wild type and SOD1(G93A) mouse lumbar motoneurons.Frontiers in cellular neuroscience · 2015Article
- Development of modified cable models to simulate accurate neuronal active behaviors.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Sequential acquisition of cacophony calcium currents, sodium channels and voltage-dependent potassium currents affects spike shape and dendrite growth during postembryonic maturation of an identified Drosophila motoneuron.The European journal of neuroscience · 2014Article
- Regulation of persistent activity in hippocampal mossy cells by inhibitory synaptic potentials.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Mechanisms underlying subunit independence in pyramidal neuron dendrites.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Asymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons.PloS one · 2014Article
- Neuromodulation impact on nonlinear firing behavior of a reduced model motoneuron with the active dendrite.Frontiers in computational neuroscience · 2014Article
- Sodium-mediated plateau potentials in lumbar motoneurons of neonatal rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Ca(v)2 channels mediate low and high voltage-activated calcium currents in Drosophila motoneurons.The Journal of physiology · 2012Article
- Contribution of intrinsic properties and synaptic inputs to motoneuron discharge patterns: a simulation study.Journal of neurophysiology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In spinal motoneurons, activation of dendritically located depolarizing conductances can lead to amplification of synaptic inputs and the production of plateau potentials. Immunohistochemical and computational studies have implicated dendritic CaV1.3 channels in this amplification and suggest that CaV1.3 channels in spinal motoneurons may be organized in clusters in the dendritic tree. Our goal was to provide physiological evidence for the presence of multiple discrete clusters of voltage-gated calcium channels in spinal motoneurons and to explore the spatial arrangement of these clusters in the dendritic tree. We recorded voltage-gated calcium currents from spinal motoneurons in slices of mature mouse spinal cords. We demonstrate that single somatic voltage-clamp steps can elicit multiple inward currents with varying delays to onset, resulting in a current with a "staircase"-like appearance. Recordings from cultured dorsal root ganglion cells at different stages of neurite development provide evidence that these currents arise from the unclamped portions of the dendritic tree. Finally, both voltage- and current-clamp data were used to constrain computer models of a motoneuron. The resultant simulations impose two conditions on the spatial distribution of CaV channels in motoneuron dendrites: one of asymmetry relative to the soma and another of spatial separation between clusters of CaV channels. We propose that this compartmentalization would provide motoneurons with the ability to process multiple sources of input in parallel and integrate this processed information to produce appropriate trains of action potentials for the intended motor behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.