ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Caenorhabditis elegans innexins regulate active zone differentiation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- In situ structure of a gap junction-stomatin complex.Science advances · 2025Article
- A modular system to label endogenous presynaptic proteins using split fluorophores in Caenorhabditis elegans.Genetics · 2025Article
- CFI-1 functions unilaterally to restrict gap junction formation in C. elegans.Development (Cambridge, England) · 2025Article
- A hyperpolarizing neuron recruits undocked innexin hemichannels to transmit neural information inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Channel-independent function of UNC-9/Innexin in spatial arrangement of GABAergic synapses ineLife · 2022Article
- NLR-1/CASPR Anchors F-Actin to Promote Gap Junction Formation.Developmental cell · 2020Article
- Gap junctions: historical discoveries and new findings in theBiology open · 2020Review
- Innexins: Expression, Regulation, and Functions.Frontiers in physiology · 2018Review
- A Pipeline for Volume Electron Microscopy of theFrontiers in neural circuits · 2018Article
- Article
- Filling the gap: adding super-resolution to array tomography for correlated ultrastructural and molecular identification of electrical synapses at the C. elegans connectome.Neurophotonics · 2016Article
- DOP-2 D2-Like Receptor Regulates UNC-7 Innexins to Attenuate Recurrent Sensory Motor Neurons during C. elegans Copulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons.Cell reports · 2015Article
- Mechanosensitive unpaired innexin channels in C. elegans touch neurons.American journal of physiology. Cell physiology · 2014Article
- Oligomeric structure and functional characterization of Caenorhabditis elegans Innexin-6 gap junction protein.The Journal of biological chemistry · 2013Article
- The F-box protein MEC-15 (FBXW9) promotes synaptic transmission in GABAergic motor neurons in C. elegans.PloS one · 2013Article
- The Schistosoma mansoni phylome: using evolutionary genomics to gain insight into a parasite's biology.BMC genomics · 2012Article
- Expanding views of presynaptic terminals: new findings from Caenorhabditis elegans.Current opinion in neurobiology · 2012Review
- Presynaptic Active Zone Density during Development and Synaptic Plasticity.Frontiers in molecular neuroscience · 2012Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
In a genetic screen for active zone defective mutants in Caenorhabditis elegans, we isolated a loss-of-function allele of unc-7, a gene encoding an innexin/pannexin family gap junction protein. Innexin UNC-7 regulates the size and distribution of active zones at C. elegans neuromuscular junctions. Loss-of-function mutations in another innexin, UNC-9, cause similar active zone defects as unc-7 mutants. In addition to presumptive gap junction localizations, both UNC-7 and UNC-9 are also localized perisynaptically throughout development and required in presynaptic neurons to regulate active zone differentiation. Our mosaic analyses, electron microscopy, as well as expression studies suggest a novel and likely nonjunctional role of specific innexins in active zone differentiation in addition to gap junction formations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.