ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Complex intrinsic membrane properties and dopamine shape spiking activity in a motor axon.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- High-Pass Filtering through Short-Term Synaptic Facilitation Amplifies Low-Frequency Modulation of Bursting Input.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The influence of hyperpolarization-activated cation current on conduction delay and failure of action potentials along axon related to abnormal functions.Cognitive neurodynamics · 2024Article
- The dynamic range of voltage-dependent gap junction signaling is maintained byJournal of neurophysiology · 2022Article
- Temperature-robust activity patterns arise from coordinated axonal Sodium channel properties.PLoS computational biology · 2020Article
- Mutual Suppression of Proximal and Distal Axonal Spike Initiation Determines the Output Patterns of a Motor Neuron.Frontiers in cellular neuroscience · 2019Article
- Molecular characterization of putative neuropeptide, amine, diffusible gas and small molecule transmitter biosynthetic enzymes in the eyestalk ganglia of the American lobster, Homarus americanus.Invertebrate neuroscience : IN · 2018Article
- Ionic mechanisms underlying history-dependence of conduction delay in an unmyelinated axon.eLife · 2017Article
- Axonal Conduction Velocity Measurement.Bio-protocol · 2017Article
- Role of Ih in differentiating the dynamics of the gastric and pyloric neurons in the stomatogastric ganglion of the lobster, Homarus americanus.Journal of neurophysiology · 2016Article
- Axonal activity in vivo: technical considerations and implications for the exploration of neural circuits in freely moving animals.Frontiers in neuroscience · 2015Review
- Automatic parameter estimation of multicompartmental neuron models via minimization of trace error with control adjustment.Journal of neurophysiology · 2014Article
- A computational paradigm for dynamic logic-gates in neuronal activity.Frontiers in computational neuroscience · 2014Article
- Sudden synchrony leaps accompanied by frequency multiplications in neuronal activity.Frontiers in neural circuits · 2013Article
- Removal of default state-associated inhibition during repetition priming improves response articulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Dopamine modulation of Ih improves temporal fidelity of spike propagation in an unmyelinated axon.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Information transmission in cercal giant interneurons is unaffected by axonal conduction noise.PloS one · 2012Article
- Beyond faithful conduction: short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axon.Progress in neurobiology · 2011Review
- Neural circuit flexibility in a small sensorimotor system.Current opinion in neurobiology · 2011Review
- Localization and function of Ih channels in a small neural network.Journal of neurophysiology · 2011Article
- Dynamics of excitability over extended timescales in cultured cortical neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
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2 authors.
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Abstract
We studied the peripheral motor axons of the two pyloric dilator (PD) neurons of the stomatogastric ganglion in the lobster, Homarus americanus. Intracellular recordings from the motor nerve showed both fast and slow voltage- and activity-dependent dynamics. During rhythmic bursts, the PD axons displayed changes in spike amplitude and duration. Pharmacological experiments and the voltage dependence of these phenomena suggest that inactivation of sodium and A-type potassium channels are responsible. In addition, the "resting" membrane potential was dependent on ongoing spike or burst activity, with more hyperpolarized values when activity was strong. Nerve stimulations, pharmacological block and current clamp experiments suggest that this is due to a functional antagonism between a slow after-hyperpolarization (sAHP) and inward rectification through hyperpolarization-activated current (IH). Dopamine application resulted in modest depolarization and "ectopic" peripheral spike initiation in the absence of centrally generated activity. This effect was blocked by CsCl and ZD7288, consistent with a role of IH. High frequency nerve stimulation inhibited peripheral spike initiation for several seconds, presumably due to the sAHP. Both during normal bursting activity and antidromic nerve stimulation, the conduction delay over the length of the peripheral nerve changed in a complex manner. This suggests that axonal membrane dynamics can have a substantial effect on the temporal fidelity of spike patterns propagated from a spike initiation site to a synaptic target, and that neuromodulators can influence the extent to which spike patterns are modified.
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