ArticleThe Journal of general virology2009
Chlorella viruses prevent multiple infections by depolarizing the host membrane.
Article in The Journal of general virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Genomic diversity and global distribution of four new prasinoviruses from the tropical north Pacific.Microbiology spectrum · 2025Article
- Yaravirus brasiliense genomic structure analysis and its possible influence on the metabolism.Genetics and molecular biology · 2025Article
- Temperature modulates dominance of a superinfecting Arctic virus in its unicellular algal host.The ISME journal · 2024Article
- Efficient assays to quantify the life history traits of algal viruses.Applied and environmental microbiology · 2023Article
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- Strong selection and high mutation supply characterize experimental Chlorovirus evolution.Virus evolution · 2022Article
- Chloroviruses.Viruses · 2019Review
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- Chloroviruses Have a Sweet Tooth.Viruses · 2017Review
- Article
- Deep RNA sequencing reveals hidden features and dynamics of early gene transcription in Paramecium bursaria chlorella virus 1.PloS one · 2014Article
- A virus-encoded potassium ion channel is a structural protein in the chlorovirus Paramecium bursaria chlorella virus 1 virion.The Journal of general virology · 2013Article
- Potassium ion channels: could they have evolved from viruses?Plant physiology · 2013Review
- Structural organization of DNA in chlorella viruses.PloS one · 2012Article
- Phycodnavirus potassium ion channel proteins question the virus molecular piracy hypothesis.PloS one · 2012Article
- Chloroviruses: not your everyday plant virus.Trends in plant science · 2012Review
- Viral proteins function as ion channels.Biochimica et biophysica acta · 2011Review
- DNA viruses: the really big ones (giruses).Annual review of microbiology · 2010Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Previous experiments established that when the unicellular green alga Chlorella NC64A is inoculated with two viruses, usually only one virus replicates in a single cell. That is, the viruses mutually exclude one another. In the current study, we explore the possibility that virus-induced host membrane depolarization, at least partially caused by a virus-encoded K(+) channel (Kcv), is involved in this mutual exclusion. Two chlorella viruses, PBCV-1 and NY-2A, were chosen for the study because (i) they can be distinguished by real-time PCR and (ii) they exhibit differential sensitivity to Cs(+), a well-known K(+) channel blocker. PBCV-1-induced host membrane depolarization, Kcv channel activity and plaque formation are only slightly affected by Cs(+), whereas all three NY-2A-induced events are strongly inhibited by Cs(+). The addition of one virus 5-15 min before the other results primarily in replication of the first virus. However, if virus NY-2A-induced membrane depolarization of the host is blocked by Cs(+), PBCV-1 is not excluded. We conclude that virus-induced membrane depolarization is at least partially responsible for the exclusion phenomenon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.