Evidence map›Paper›PMID 19386744›Full record

Trial reportThe American journal of clinical nutrition2009

Vitamin K supplementation and progression of coronary artery calcium in older men and women.

M Kyla Shea, Christopher J O'Donnell, Udo Hoffmann, Gerard E Dallal, Bess Dawson-Hughes, José M Ordovas, Paul A Price, Matthew K Williamson, Sarah L Booth

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 110 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 8 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00183001 phase3completednot on this map

Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification

TypeinterventionalSponsorNational Institute on Aging (NIA)Ran2001 to 2006Enrolled452ConditionsOsteoporosis, Vascular Calcification, InflammationArmsVitamin K
NCT03813550 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Intestinal Microbiota and Vitamin K Levels in PXE Patients (IMPROVE Study)

TypeinterventionalSponsorUniversity Hospital, AngersRan2019 to 2020Enrolled20ConditionsPseudoxanthoma ElasticumArmsFecal and blood samples
3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 8 syntheses or guidelines pooled it, 274 citations in OpenAlex.

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  8. Vitamin K for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2015
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  11. The effect of Vitamin-KJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

M Kyla SheaUS Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
Christopher J O'Donnell
Udo Hoffmann
Gerard E Dallal
Bess Dawson-Hughes
José M Ordovas
Paul A Price
Matthew K Williamson
Sarah L Booth
Tufts University · US

Funding

Nutrition &Cardiovascular Disease Training ProgramT32HL069772 · NHLBI · TUFTS UNIVERSITY BOSTON · PI LICHTENSTEIN, ALICE H · 2003 to 2017
$2.1M
Vitamin K: vascular calcification and age-related bone *R01HL069272 · NHLBI · TUFTS UNIVERSITY BOSTON · PI BOOTH, SARAH LOUISE · 2001 to 2004
$1.0M
VITAMIN K INSUFFICIENCY--A RISK FACTOR FOR OSTEOPOROSISR01AG014759 · NIA · TUFTS UNIVERSITY BOSTON · PI BOOTH, SARAH · 1998 to 2001
$610k
NHLBI NIH HHS HL69272NHLBI NIH HHS R01 HL069272NHLBI NIH HHS T32 HL069772NHLBI NIH HHS T32HL69772NIA NIH HHS AG14759
6 · The paper itself

Abstract

backgroundCoronary artery calcification (CAC) is an independent predictor of cardiovascular disease. A preventive role for vitamin K in CAC progression has been proposed on the basis of the properties of matrix Gla protein (MGP) as a vitamin K-dependent calcification inhibitor.

objectiveThe objective was to determine the effect of phylloquinone (vitamin K1) supplementation on CAC progression in older men and women.

designCAC was measured at baseline and after 3 y of follow-up in 388 healthy men and postmenopausal women; 200 received a multivitamin with 500 microg phylloquinone/d (treatment), and 188 received a multivitamin alone (control).

resultsIn an intention-to-treat analysis, there was no difference in CAC progression between the phylloquinone group and the control group; the mean (+/-SEM) changes in Agatston scores were 27 +/- 6 and 37 +/- 7, respectively. In a subgroup analysis of participants who were > or =85% adherent to supplementation (n = 367), there was less CAC progression in the phylloquinone group than in the control group (P = 0.03). Of those with preexisting CAC (Agatston score > 10), those who received phylloquinone supplements had 6% less progression than did those who received the multivitamin alone (P = 0.04). Phylloquinone-associated decreases in CAC progression were independent of changes in serum MGP. MGP carboxylation status was not determined.

conclusionsPhylloquinone supplementation slows the progression of CAC in healthy older adults with preexisting CAC, independent of its effect on total MGP concentrations. Because our data are hypothesis-generating, further studies are warranted to clarify this mechanism. This trial was registered at clinicaltrials.gov as NCT00183001.

Indexed as

Dietary SupplementsAgedCalcinosisCalciumCalcium-Binding ProteinsCoronary AngiographyCoronary VesselsC-Reactive ProteinDouble-Blind MethodExtracellular Matrix ProteinsFemaleHumansInterleukin-6MaleMatrix Gla ProteinMiddle AgedCalciumCalcium-Binding ProteinsC-Reactive ProteinExtracellular Matrix ProteinsInterleukin-6Matrix Gla ProteinOsteoprotegerinVitamin KVitamins

Identifiers

PMID19386744
PMCPMC2682995
OpenAlexW2074465767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.