ArticleJournal of virology2009
A point mutation, E95D, in the mumps virus V protein disengages STAT3 targeting from STAT1 targeting.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Fluorescence Imaging of Viral Sialidase Activity Using a Fluorogenic Probe.Advances in experimental medicine and biology · 2026Review
- The regulatory roles of STAT3 protein in the pathogenesis of viral infections.Frontiers in cellular and infection microbiology · 2025Review
- Review
- Evolutionary history of cotranscriptional editing in the paramyxoviral phosphoprotein gene.Virus evolution · 2021Review
- The Dynamic Interface of Viruses with STATs.Journal of virology · 2020Review
- A Single Point Mutation in the Mumps V Protein Alters Targeting of the Cellular STAT Pathways Resulting in Virus Attenuation.Viruses · 2019Article
- STAT3 roles in viral infection: antiviral or proviral?Future virology · 2018Review
- Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism.Frontiers in immunology · 2017Review
- Recombinant mumps virus as a cancer therapeutic agent.Molecular therapy oncolytics · 2016Article
- Molecular biology, pathogenesis and pathology of mumps virus.The Journal of pathology · 2015Review
- Easy and Rapid Detection of Mumps Virus by Live Fluorescent Visualization of Virus-Infected Cells.PloS one · 2015Article
- The rabies virus interferon antagonist P protein interacts with activated STAT3 and inhibits Gp130 receptor signaling.Journal of virology · 2013Article
- Paramyxovirus evasion of innate immunity: Diverse strategies for common targets.World journal of virology · 2013Review
- The V protein of Tioman virus is incapable of blocking type I interferon signaling in human cells.PloS one · 2013Article
- Ubiquitination-mediated regulation of interferon responses.Growth factors (Chur, Switzerland) · 2012Review
- Interaction of mumps virus V protein variants with STAT1-STAT2 heterodimer: experimental and theoretical studies.Virology journal · 2010Article
- Viral hijacking of the host ubiquitin system to evade interferon responses.Current opinion in microbiology · 2010Review
- Mumps virus Enders strain is sensitive to interferon (IFN) despite encoding a functional IFN antagonist.The Journal of general virology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Mumps virus, like other paramyxoviruses in the Rubulavirus genus, encodes a V protein that can assemble a ubiquitin ligase complex from cellular components, leading to the destruction of cellular signal transducer and activator of transcription (STAT) proteins. While many V proteins target the interferon-activated STAT1 or STAT2 protein, mumps virus V protein is unique in its ability to also target STAT3 for ubiquitin modification and proteasome-mediated degradation. Here we report that a single amino acid substitution in the mumps virus V protein, E95D, results in defective STAT3 targeting while maintaining the ability to target STAT1. Results indicate that the E95D mutation disrupts the ability of the V protein to associate with STAT3. A recombinant mumps virus carrying the E95D mutation in its P and V proteins replicates normally in cultured cells but fails to induce targeting of STAT3. Infection with the recombinant virus results in the differential regulation of a number of cellular genes compared to wild-type mumps virus and increases cell death in infected cells, producing a large-plaque phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.