ArticleSchizophrenia bulletin2009
Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal Study.
Article in Schizophrenia bulletin, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06928935 (Digital Dialectical Behavioural Therapy), which is not on this map. Cited by 166 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Digital Dialectical Behavioural Therapy (d-DBT) for Youth at Clinical High Risk (CHR) for Psychosis: An Exploratory Multi-Methods Study
Who cites it
166 citing papers in PubMed, 6 syntheses or guidelines pooled it, 401 citations in OpenAlex.
- Comorbid Personality Disorders in Individuals With an At-Risk Mental State for Psychosis: A Meta-Analytic Review.Frontiers in psychiatry · 2019Pooled it
- Can We Predict Psychosis Outside the Clinical High-Risk State? A Systematic Review of Non-Psychotic Risk Syndromes for Mental Disorders.Schizophrenia bulletin · 2018Pooled it
- The Dark Side of the Moon: Meta-analytical Impact of Recruitment Strategies on Risk Enrichment in the Clinical High Risk State for Psychosis.Schizophrenia bulletin · 2016Pooled it
- Comorbid depressive and anxiety disorders in 509 individuals with an at-risk mental state: impact on psychopathology and transition to psychosis.Schizophrenia bulletin · 2014Pooled it
- At risk for schizophrenic or affective psychoses? A meta-analysis of DSM/ICD diagnostic outcomes in individuals at high clinical risk.Schizophrenia bulletin · 2013Pooled it
- Predicting the risk of psychosis onset: advances and prospects.Early intervention in psychiatry · 2012Pooled it
- Depression, family interaction and family intervention in adolescents at clinical-high risk for psychosis.Early intervention in psychiatry · 2021Trial
- Glycine treatment of the risk syndrome for psychosis: report of two pilot studies.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2013Trial
- Trial
- Rationale and baseline characteristics of PREVENT: a second-generation intervention trial in subjects at-risk (prodromal) of developing first-episode psychosis evaluating cognitive behavior therapy, aripiprazole, and placebo for the prevention of psychosis.Schizophrenia bulletin · 2011Trial
- Correlation of individual differences in schizotypal personality traits with amphetamine-induced dopamine release in striatal and extrastriatal brain regions.The American journal of psychiatry · 2011Trial
- Psychosocial Interventions, Recovery, and Mediating Mechanisms in Schizophrenia-Spectrum Disorders: A Systematic Review and Meta-Analysis of Longitudinal Studies.Brain sciences · 2026Review
- Gender differences in semantic facilitation and verbal recall in schizotypal personality disorder.Schizophrenia (Heidelberg, Germany) · 2026Article
- Spontaneous head movements during virtual clinical interviews help predict 12-months clinical outcomes in youth at clinical high risk for psychosis.Schizophrenia (Heidelberg, Germany) · 2025Article
- Shift in sex and age of individuals at a clinical high risk (CHR) for psychosis: relation to differences in recruitment methods and effect on sample characteristics.Schizophrenia (Heidelberg, Germany) · 2025Article
- Automated analysis of clinical interviews indicates altered head movements during social interactions in youth at clinical high-risk for psychosis.Schizophrenia (Heidelberg, Germany) · 2025Article
- Serum NR1 and NR2 concentrations in first-episode schizophrenia and clinical high-risk for psychosis.BMC psychiatry · 2025Article
- Spurious autobiographical memories of psychosis: a dopamine-gated neuroplasticity account for relapse and treatment-resistant psychosis.Psychological medicine · 2025Review
- Attenuated mental symptoms in the general population: first data from the observational cross-sectional ATTENTION study in Greece.CNS spectrums · 2025Observational
- Combinations and Temporal Associations Among Precursor Symptoms Before a First Episode of Psychosis.Schizophrenia bulletin · 2024Article
106 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 9 institutions in 2 countries.
Funding
Abstract
Treatment and prevention studies over the past decade have enrolled patients believed to be at risk for future psychosis. These patients were considered at risk for psychosis by virtue of meeting research criteria derived from retrospective accounts of the psychosis prodrome. This study evaluated the diagnostic validity of the prospective "prodromal risk syndrome" construct. Patients assessed by the Structured Interview for Prodromal Syndromes as meeting criteria of prodromal syndromes (n = 377) from the North American Prodrome Longitudinal Study were compared with normal comparison (NC, n = 196), help-seeking comparison (HSC, n = 198), familial high-risk (FHR, n = 40), and schizotypal personality disorder (SPD, n = 49) groups. Comparisons were made on variables from cross-sectional demographic, symptom, functional, comorbid diagnostic, and family history domains of assessment as well as on follow-up outcome. Prodromal risk syndrome patients as a group were robustly distinguished from NC subjects across all domains and distinguished from HSC subjects and from FHR subjects on most measures in many of these domains. Adolescent and young adult SPD patients, while distinct from prodromal patients on definitional grounds, were similar to prodromals on multiple measures, consistent with SPD in young patients possibly being an independent risk syndrome for psychosis. The strong evidence of diagnostic validity for the prodromal risk syndrome for first psychosis raises the question of its evaluation for inclusion in Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.