ArticleBMC infectious diseases2009
Serum procalcitonin for the early recognition of nosocomial infection in the critically ill patients: a preliminary report.
Article in BMC infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02130986 (Procalcitonin Antibiotic Consensus Trial), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Procalcitonin Antibiotic Consensus Trial (ProACT)
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Systematic review of studies investigating ventilator associated pneumonia diagnostics in intensive care.BMC pulmonary medicine · 2021Pooled it
- Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Guideline
- Trial
- Ventilator-associated pneumonia: pathobiological heterogeneity and diagnostic challenges.Nature communications · 2024Review
- Accuracy of the clinical pulmonary infection score to differentiate ventilator-associated tracheobronchitis from ventilator-associated pneumonia.Annals of intensive care · 2020Article
- Procalcitonin kinetics after burn injury and burn surgery in septic and non-septic patients - a retrospective observational study.BMC anesthesiology · 2018Observational
- Is Procalcitonin Useful in Pediatric Critical Care Patients?Biomarker insights · 2018Review
- Checking procalcitonin suitability for prognosis and antimicrobial therapy monitoring in burn patients.Burns & trauma · 2018Article
- Biomarker-guided antifungal therapy in patients with suspected invasive candidiasis: Ready for prime time?Intensive care medicine · 2017Article
- Strategies to Reduce Mortality in Adult and Neonatal Candidemia in Developing Countries.Journal of fungi (Basel, Switzerland) · 2017Review
- Biomarker kinetics in the prediction of VAP diagnosis: results from the BioVAP study.Annals of intensive care · 2016Article
- The intensive care infection score - a novel marker for the prediction of infection and its severity.Critical care (London, England) · 2016Article
- The importance of serum procalcitonin in diagnosis and treatment of serious bacterial infections and sepsis.Materia socio-medica · 2013Review
- Role of biomarkers in the management of antibiotic therapy: an expert panel review II: clinical use of biomarkers for initiation or discontinuation of antibiotic therapy.Annals of intensive care · 2013Article
- A composite score combining procalcitonin, C-reactive protein and temperature has a high positive predictive value for the diagnosis of intensive care-acquired infections.BMC infectious diseases · 2013Article
- Procalcitonin and procalcitonin kinetics for diagnosis and prognosis of intravascular catheter-related bloodstream infections in selected critically ill patients: a prospective observational study.BMC infectious diseases · 2012Article
- Procalcitonin in acute cardiac patients.Internal and emergency medicine · 2011Review
- Assessment of procalcitonin to predict outcome in hypothermia-treated patients after cardiac arrest.Critical care research and practice · 2011Article
- Acute phase proteins and white blood cell levels for prediction of infectious complications in status epilepticus.Critical care (London, England) · 2011Article
- Value of procalcitonin for diagnosis of early onset pneumonia in hypothermia-treated cardiac arrest patients.Intensive care medicine · 2010Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe usefulness of procalcitonin (PCT) measurement in critically ill medical patients with suspected nosocomial infection is unclear. The aim of the study was to assess PCT value for the early diagnosis of bacterial nosocomial infection in selected critically ill patients.
methodsAn observational cohort study in a 15-bed intensive care unit was performed. Seventy patients with either proven (n = 47) or clinically suspected but not confirmed (n = 23) nosocomial infection were included. Procalcitonin measurements were obtained the day when the infection was suspected (D0) and at least one time within the 3 previous days (D-3 to D0). Patients with proven infection were compared to those without. The diagnostic value of PCT on D0 was determined through the construction of the corresponding receiver operating characteristic (ROC) curve. In addition, the predictive value of PCT variations preceding the clinical suspicion of infection was assessed.
resultsPCT on D0 was the best predictor of proven infection in this population of ICU patients with a clinical suspicion of infection (AUROCC = 0.80; 95% CI, 0.68-0.91). Thus, a cut-off value of 0.44 ng/mL provides sensitivity and specificity of 65.2% and 83.0%, respectively. Procalcitonin variation between D-1 and D0 was calculated in 45 patients and was also found to be predictive of nosocomial infection (AUROCC = 0.89; 95% CI, 0.79-0.98) with a 100% positive predictive value if the +0.26 ng/mL threshold value was applied. Comparable results were obtained when PCT variation between D-2 and D0, or D-3 and D0 were considered. In contrast, CRP elevation, leukocyte count and fever had a poor predictive value in our population.
conclusionPCT monitoring could be helpful in the early diagnosis of nosocomial infection in the ICU. Both absolute values and variations should be considered and evaluated in further studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.