Evidence map›Paper›PMID 19385727›Full record

ReviewAnnual review of microbiology2009

Regulation of translation initiation by RNA binding proteins.

Paul Babitzke, Carol S Baker, Tony Romeo

Abstract readReview
In one paragraph

Review in Annual review of microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 150 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. X-Ray Exposure Induces Structural Changes in Human Breast Proteins.International journal of molecular sciences · 2025
    Article
  8. Article
  9. Article
  10. Selection ofInsects · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Stress-Induced Eukaryotic Translational Regulatory Mechanisms.Journal of clinical and medical sciences · 2024
    Article
  17. RNA binding proteins as mediators of pathological cardiac remodeling.Frontiers in cell and developmental biology · 2024
    Review
  18. Article
  19. Article
  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Paul BabitzkeDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. pxb28@psu.edu
Carol S Baker
Tony Romeo
Pennsylvania State University · USUniversity of Florida · US

Funding

Mechanism of CsrA-mediated global regulationR01GM059969 · NIGMS · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI BABITZKE, PAUL L, ROMEO, TONY · 1999 to 2021
$7.6M
Biofilm Formation and Dispersal MechanismsR01GM066794 · NIGMS · UNIVERSITY OF FLORIDA · PI ROMEO, TONY · 2003 to 2011
$2.5M
MECHANISM OF TRP GENE REGULATION BY TRAP-RNA RECOGNITIONR01GM052840 · NIGMS · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI BABITZKE, PAUL L · 1995 to 2009
$1.9M
NIGMS NIH HHS GM52840NIGMS NIH HHS GM59969NIGMS NIH HHS GM66794NIGMS NIH HHS R01 GM052840NIGMS NIH HHS R01 GM059969NIGMS NIH HHS R01 GM066794
6 · The paper itself

Abstract

RNA binding proteins are capable of regulating translation initiation by a variety of mechanisms. Although the vast majority of these regulatory mechanisms involve translational repression, one example of translational activation has been characterized in detail. The RNA recognition targets of these regulatory proteins exhibit a wide range in structural complexity, with some proteins recognizing complex pseudoknot structures and others binding to simple RNA hairpins and/or short repeated single-stranded sequences. In some instances the bound protein directly competes with ribosome binding, and in other instances the bound protein promotes formation of an RNA structure that inhibits ribosome binding. Examples also exist in which the bound protein traps the ribosome in a complex that is incapable of initiating translation.

Indexed as

Gene Expression RegulationPeptide Chain Initiation, TranslationalBase SequenceModels, MolecularMolecular Sequence DataNucleic Acid ConformationRibosomesRNARNA-Binding ProteinsRNARNA-Binding Proteins

Identifiers

PMID19385727
PMCPMC4682898
OpenAlexW2164308667

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.